Tang H Z, Lu X F, Wang K J, Ou Y S, Huang Y Q
Chin Med J (Engl). 1989 Jan;102(1):18-23.
To clarify the rule of monoamine in cerebral ischemia, 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) in cerebrospinal fluid (CSF) of 33 patients and 18 controls were measured with high performance liquid chromatography. Results showed all the three metabolites increased in patients with severe ischemia but only MHPG and 5-HIAA increased significantly. MHPG changed more quickly and regularly in cerebral ischemia than the other two. A positive correlation between any couple of the metabolites was found in both the controls and patients in the first week after stroke, but it was disturbed at the end of the second week. Computer-assisted multivariate analysis indicated that 5-HIAA and MHPG are more closely related to the state of illness in the acute stage while HVA the least. Possible explanations for the changes of CSF levels of amine metabolites were discussed.
为阐明单胺在脑缺血中的规律，采用高效液相色谱法测定了33例患者和18例对照者脑脊液（CSF）中的3-甲氧基-4-羟基苯乙二醇（MHPG）、5-羟吲哚乙酸（5-HIAA）和高香草酸（HVA）。结果显示，重度缺血患者的这三种代谢产物均升高，但仅MHPG和5-HIAA显著升高。在脑缺血中，MHPG的变化比其他两种代谢产物更快且更有规律。在卒中后的第一周，对照组和患者的这三种代谢产物之间均呈正相关，但在第二周结束时这种相关性受到干扰。计算机辅助多变量分析表明，在急性期，5-HIAA和MHPG与病情的关系更为密切，而HVA与病情的关系最不密切。文中讨论了脑脊液中胺类代谢产物水平变化的可能原因。
