Takahashi K, Segal E, Kondo T, Mukai T, Moriyama M, Takahashi M, Yamanishi K
Department of Virology, Osaka University, Japan.
Pediatr Infect Dis J. 1992 May;11(5):369-73. doi: 10.1097/00006454-199205000-00006.
Early immune response was studied by assessing interferon (IFN) and natural killer cell activity in 13 patients with exanthem subitum associated with human herpesvirus 6 infection during the acute and convalescent phases. Only IFN-alpha showed a significant increase in the plasma of patients during the acute febrile phase compared with the convalescent period. The inhibitory effect of IFN-alpha and IFN-beta on human herpesvirus 6 replication was demonstrated in vitro with cord blood mononuclear cells. Natural killer cell activity was also significantly augmented in the acute phase, especially in the exanthem period, rather than in the convalescent phase (P less than 0.01). These results suggest that the enhanced IFN-alpha response and natural killer cell activity in the acute early phase of the disease may play pivotal roles in the recovery from exanthem subitum.
通过评估13例幼儿急疹伴人疱疹病毒6感染患者在急性期和恢复期的干扰素（IFN）及自然杀伤细胞活性，对早期免疫反应进行了研究。与恢复期相比，仅α干扰素在急性发热期患者血浆中显著升高。体外实验利用脐血单个核细胞证实了α干扰素和β干扰素对人疱疹病毒6复制具有抑制作用。急性期自然杀伤细胞活性也显著增强，尤其是在出疹期，而非恢复期（P<0.01）。这些结果提示，疾病急性早期增强的α干扰素反应和自然杀伤细胞活性可能在幼儿急疹的恢复过程中起关键作用。
