小鼠4号染色体与人类9号染色体的比较图谱：Lv、Orm和Hxb在小鼠4号染色体上紧密连锁。
Comparative mapping of mouse chromosome 4 and human chromosome 9: Lv, Orm, and Hxb are closely linked on mouse chromosome 4.
作者信息
Pilz A, Moseley H, Peters J, Abbott C
机构信息
Department of Genetics & Biometry, University College London, UK.
出版信息
Mamm Genome. 1992;3(5):247-9. doi: 10.1007/BF00292151.
The genes for orosomucoid (ORM-1 and ORM-2), delta-aminolevulinate dehydratase (ALAD), and hexabrachion or tenascin (HXB) all map to the q31-qter region of human Chromosome (Chr) 9. The mouse homolog of each of these genes has been mapped to Chr4, but hexabrachion has not previously been mapped by linkage analysis. We have now ordered Orm-1, Lv (the mouse homolog of ALAD), and Hxb in an interspecific backcross panel, by use of tyrosinase related protein-1, Tyrp-1, whose human homolog maps to 9p13-pter (Abbott et al., Genomics 1991) as a reference locus. No recombinants were identified in 124 animals between Lv and Orm-1. Hxb was found to be 1.6 cM distal to Lv and Orm-1, and 4.8 cM proximal to Tyrp-1, or b. These data therefore contribute to our knowledge of the conserved synteny between HSA 9q and MMU 4.
类粘蛋白（ORM-1和ORM-2）、δ-氨基乙酰丙酸脱水酶（ALAD）以及六臂蛋白或腱生蛋白（HXB）的基因均定位于人类9号染色体（Chr）的q31-qter区域。这些基因各自的小鼠同源基因已被定位于4号染色体，但此前尚未通过连锁分析对六臂蛋白进行定位。我们现在通过使用酪氨酸酶相关蛋白-1（Tyrp-1），在一个种间回交群体中对Orm-1、Lv（ALAD的小鼠同源基因）和Hxb进行了排序，其人类同源基因定位于9p13-pter（Abbott等人，《基因组学》，1991年）作为参考位点。在124只动物中未发现Lv和Orm-1之间存在重组。发现Hxb位于Lv和Orm-1的远端1.6 cM处，以及Tyrp-1或b的近端4.8 cM处。因此，这些数据有助于我们了解人类9号染色体长臂（HSA 9q）和小鼠4号染色体（MMU 4）之间保守的同线性。
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