Rezabek G H, Friedman A D
Department of Pediatrics, St Louis University School of Medicine, Missouri.
Drugs. 1992 May;43(5):674-82. doi: 10.2165/00003495-199243050-00004.
Superficial fungal infections are common. Most diagnoses of fungal infections of the skin can be made by physical examination, assisted by the use of a Wood's lamp, skin scrapings for microscopic examination, and fungal cultures. Dermatophyte infections are common at all ages, in both sexes, and they have a worldwide distribution. These infections include tinea capitis, tinea cruris, tinea pedis, tinea corporis, tinea manuum and tinea barbae. Tinea versicolor, caused by Malassezia furfur, and candidal infections are also common. Treatment modalities include oral and topical agents. Good personal hygiene is an important adjunct to antifungal therapy. Decisions regarding the appropriateness of therapy in a given patient must take into account the extent and location of the infection, the benefits and risks of each of the treatments, and cost. Oral therapies include griseofulvin, ketoconazole, and itraconazole. There are a large variety of topical treatments, including nystatin, selenium sulfide, tolnaftate, haloprogin, miconazole, clotrimazole, and sodium thiosulfate. Important to successful treatment is compliance with what is sometimes a long course of treatment, and good personal hygiene.
浅表真菌感染很常见。大多数皮肤真菌感染的诊断可通过体格检查做出,借助伍德灯、用于显微镜检查的皮肤刮屑以及真菌培养。皮肤癣菌感染在各年龄段、男女中均很常见,且在全球范围内都有分布。这些感染包括头癣、股癣、足癣、体癣、手癣和须癣。由糠秕马拉色菌引起的花斑癣以及念珠菌感染也很常见。治疗方式包括口服和外用药物。良好的个人卫生是抗真菌治疗的重要辅助措施。在特定患者中决定治疗的适宜性时,必须考虑感染的范围和部位、每种治疗的益处和风险以及成本。口服治疗药物包括灰黄霉素、酮康唑和伊曲康唑。有多种外用治疗药物,包括制霉菌素、硫化硒、托萘酯、卤普罗近、咪康唑、克霉唑和硫代硫酸钠。成功治疗的关键在于依从有时较长的治疗疗程以及保持良好的个人卫生。