Oguchi S, Iida S, Adachi H, Oshima H, Esumi H
Biochemistry Division, National Cancer Center Research Institute, Tokyo, Japan.
FEBS Lett. 1992 Aug 10;308(1):22-5. doi: 10.1016/0014-5793(92)81041-j.
Ca2+/calmodulin-dependent nitric oxide synthase was found to be induced during rat liver necrosis caused by administration of Propionibacterium acnes and E. coli lipopolysaccharide to rats. Examination of the specific induction of Ca2+/calmodulin-dependent NO synthase showed that the enzyme was induced in the lung, spleen and colon as well as the liver. Northern blot analysis revealed that the induction occurred at the transcriptional level.
在给大鼠注射痤疮丙酸杆菌和大肠杆菌脂多糖导致大鼠肝坏死的过程中，发现钙/钙调蛋白依赖性一氧化氮合酶被诱导。对钙/钙调蛋白依赖性一氧化氮合酶特异性诱导的检测表明，该酶在肺、脾、结肠以及肝脏中均被诱导。Northern印迹分析显示，这种诱导发生在转录水平。
