编码小鼠红藻氨酸盐选择性谷氨酸受体通道β2亚基的cDNA的克隆及功能表达
Cloning and functional expression of a cDNA encoding the mouse beta 2 subunit of the kainate-selective glutamate receptor channel.
作者信息
Morita T, Sakimura K, Kushiya E, Yamazaki M, Meguro H, Araki K, Abe T, Mori K J, Mishina M
机构信息
Department of Neuropharmacology, Faculty of Science, Niigata University, Japan.
出版信息
Brain Res Mol Brain Res. 1992 Jun;14(1-2):143-6. doi: 10.1016/0169-328x(92)90023-5.
PMID:1379666
Abstract
The primary structure of the mouse glutamate receptor beta 2 subunit has been deduced by cloning and sequencing cDNA. The beta 2 subunit has structural characteristics common to the subunits of glutamate-gated ion channels. Expression of the cloned cDNA in Xenopus oocytes yields functional glutamate receptor channels selective for kainate.
摘要
小鼠谷氨酸受体β2亚基的一级结构已通过克隆和测序cDNA推导得出。β2亚基具有谷氨酸门控离子通道亚基共有的结构特征。在非洲爪蟾卵母细胞中表达克隆的cDNA可产生对海人藻酸有选择性的功能性谷氨酸受体通道。
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