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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Hernandez C, Aiello E

Department of Biology, University of Puerto Rico, Humacao 00661.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1992 Apr;101(3):487-92. doi: 10.1016/0742-8413(92)90075-i.

Mucociliary transport of carbon particles across the palate of anesthetized Rana pipiens was accelerated by electrical stimulation of the palatine nerve. 2. Transport was also accelerated by intracardiac injection of acetylcholine and of substance P in a dose-dependent manner. 3. Acceleration of transport by acetylcholine and by substance P was selectively blocked by atropine and by the substance P antagonist Spantide, respectively. 4. Acceleration of transport by nerve stimulation was blocked partially by atropine and by Spantide, and completely by the two administered concurrently. 5. It is concluded that nerve stimulation releases both acetylcholine and substance P or a similar neuropeptide. 6. Taken in conjunction with the literature, the data suggest that these substances are involved in the normal mechanism for stimulating mucociliary clearance of the palate in response to the presence of particles.

通过电刺激腭神经，可加速麻醉的牛蛙上腭碳颗粒的黏液纤毛运输。2. 心内注射乙酰胆碱和P物质也可加速运输，且呈剂量依赖性。3. 乙酰胆碱和P物质引起的运输加速分别被阿托品和P物质拮抗剂Spantide选择性阻断。4. 神经刺激引起的运输加速被阿托品和Spantide部分阻断，二者同时使用则完全阻断。5. 得出结论，神经刺激可释放乙酰胆碱和P物质或类似的神经肽。6. 结合文献来看，数据表明这些物质参与了因颗粒存在而刺激上腭黏液纤毛清除的正常机制。

Hernandez C, Aiello E

Department of Biology, University of Puerto Rico, Humacao 00661.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1992 Apr;101(3):487-92. doi: 10.1016/0742-8413(92)90075-i.

Mucociliary transport of carbon particles across the palate of anesthetized Rana pipiens was accelerated by electrical stimulation of the palatine nerve. 2. Transport was also accelerated by intracardiac injection of acetylcholine and of substance P in a dose-dependent manner. 3. Acceleration of transport by acetylcholine and by substance P was selectively blocked by atropine and by the substance P antagonist Spantide, respectively. 4. Acceleration of transport by nerve stimulation was blocked partially by atropine and by Spantide, and completely by the two administered concurrently. 5. It is concluded that nerve stimulation releases both acetylcholine and substance P or a similar neuropeptide. 6. Taken in conjunction with the literature, the data suggest that these substances are involved in the normal mechanism for stimulating mucociliary clearance of the palate in response to the presence of particles.

通过电刺激腭神经，可加速麻醉的牛蛙上腭碳颗粒的黏液纤毛运输。2. 心内注射乙酰胆碱和P物质也可加速运输，且呈剂量依赖性。3. 乙酰胆碱和P物质引起的运输加速分别被阿托品和P物质拮抗剂Spantide选择性阻断。4. 神经刺激引起的运输加速被阿托品和Spantide部分阻断，二者同时使用则完全阻断。5. 得出结论，神经刺激可释放乙酰胆碱和P物质或类似的神经肽。6. 结合文献来看，数据表明这些物质参与了因颗粒存在而刺激上腭黏液纤毛清除的正常机制。