齐多夫定耐药的1型人类免疫缺陷病毒RNA基因型在治疗后血清中的持续存在。
Persistence of azidothymidine-resistant human immunodeficiency virus type 1 RNA genotypes in posttreatment sera.
作者信息
Albert J, Wahlberg J, Lundeberg J, Cox S, Sandström E, Wahren B, Uhlén M
机构信息
Department of Virology, National Bacteriological Laboratory, Stockholm, Sweden.
出版信息
J Virol. 1992 Sep;66(9):5627-30. doi: 10.1128/JVI.66.9.5627-5630.1992.
Abstract
The rate of reversion from azidothymidine (zidovudine; AZT) resistance was studied by direct sequencing of human immunodeficiency virus type 1 (HIV-1) virion RNA in sera from four patients who discontinued long-term treatment. Before cessation of treatment, all four patients harbored HIV-1 with multiple mutations reported to confer AZT resistance. In three patients, slow reversions of these mutations starting after 9, 9, and 18 months were detected. The slow reversions indicate that AZT-resistant HIV-1 variants are likely to have an unaltered replicative capacity and pathogenic potential. Furthermore, there were discrepancies between the in vivo RNA sequences and the sequences of virus isolates, indicating that the isolation procedure may select for nonrepresentative virus variants.
摘要
通过对4名停止长期治疗患者血清中的1型人类免疫缺陷病毒（HIV-1）病毒体RNA进行直接测序，研究了从叠氮胸苷（齐多夫定；AZT）耐药性逆转的速率。在停止治疗前，所有4名患者携带的HIV-1都有多个据报道可导致AZT耐药性的突变。在3名患者中，检测到这些突变在9个月、9个月和18个月后开始缓慢逆转。这些缓慢逆转表明，对AZT耐药的HIV-1变体可能具有未改变的复制能力和致病潜力。此外，体内RNA序列与病毒分离株序列之间存在差异，这表明分离程序可能会选择非代表性的病毒变体。
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本文引用的文献
1
The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial.叠氮胸苷（AZT）治疗艾滋病及艾滋病相关综合征患者的疗效。一项双盲、安慰剂对照试验。
N Engl J Med. 1987 Jul 23;317(4):185-91. doi: 10.1056/NEJM198707233170401.
2
Biologic features of HIV-1 that correlate with virulence in the host.与宿主中致病力相关的HIV-1生物学特征。
Science. 1988 Apr 1;240(4848):80-2. doi: 10.1126/science.2832945.
3
Avoiding false positives with PCR.避免聚合酶链反应（PCR）出现假阳性结果。
Nature. 1989 May 18;339(6221):237-8. doi: 10.1038/339237a0.
4
Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations.体内HIV准种的时间波动并未通过连续的HIV分离得以体现。
Cell. 1989 Sep 8;58(5):901-10. doi: 10.1016/0092-8674(89)90942-2.
5
Human immunodeficiency virus type 1 p24 production and antigenic variation in tissue culture of isolates with various growth characteristics.
J Med Virol. 1989 Nov;29(3):170-5. doi: 10.1002/jmv.1890290305.
6
Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT).HIV-1逆转录酶中的多个突变赋予对齐多夫定（AZT）的高水平耐药性。
Science. 1989 Dec 1;246(4934):1155-8. doi: 10.1126/science.2479983.
7
HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy.在长期治疗期间分离出的对齐多夫定（AZT）敏感性降低的HIV。
Science. 1989 Mar 31;243(4899):1731-4. doi: 10.1126/science.2467383.
8
Simple, sensitive, and specific detection of human immunodeficiency virus type 1 in clinical specimens by polymerase chain reaction with nested primers.采用巢式引物聚合酶链反应对临床标本中的1型人类免疫缺陷病毒进行简单、灵敏且特异的检测。
J Clin Microbiol. 1990 Jul;28(7):1560-4. doi: 10.1128/jcm.28.7.1560-1564.1990.
9
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J Virol. 1991 Nov;65(11):6266-76. doi: 10.1128/JVI.65.11.6266-6276.1991.
10
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AIDS Res Hum Retroviruses. 1991 Dec;7(12):983-90. doi: 10.1089/aid.1991.7.983.
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