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Persistence of azidothymidine-resistant human immunodeficiency virus type 1 RNA genotypes in posttreatment sera.齐多夫定耐药的1型人类免疫缺陷病毒RNA基因型在治疗后血清中的持续存在。
J Virol. 1992 Sep;66(9):5627-30. doi: 10.1128/JVI.66.9.5627-5630.1992.
2
Zidovudine-resistant human immunodeficiency virus type 1 genomes detected in plasma distinct from viral genomes in peripheral blood mononuclear cells.在血浆中检测到的对齐多夫定耐药的1型人类免疫缺陷病毒基因组与外周血单个核细胞中的病毒基因组不同。
J Infect Dis. 1993 Feb;167(2):445-8. doi: 10.1093/infdis/167.2.445.
3
Characterization of reverse transcriptase activity and susceptibility to other nucleosides of AZT-resistant variants of HIV-1. Results from the Canadian AZT Multicentre Study.HIV-1齐多夫定耐药变异体的逆转录酶活性及对其他核苷敏感性的特征分析。加拿大齐多夫定多中心研究结果。
Ann N Y Acad Sci. 1990;616:346-55. doi: 10.1111/j.1749-6632.1990.tb17855.x.
4
Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine.人类免疫缺陷病毒1型逆转录酶基因中的新型突变，该突变编码对2',3'-双脱氧肌苷和2',3'-双脱氧胞苷的交叉耐药性。
J Virol. 1992 Dec;66(12):7128-35. doi: 10.1128/JVI.66.12.7128-7135.1992.
5
Quantitation of zidovudine-resistant human immunodeficiency virus type 1 in the blood of treated and untreated patients.接受治疗和未接受治疗患者血液中耐齐多夫定的1型人类免疫缺陷病毒的定量分析。
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Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase.HIV-1逆转录酶突变导致对去羟肌苷的耐药性及对叠氮胸苷的敏感性。
Science. 1991 Sep 27;253(5027):1557-9. doi: 10.1126/science.1716788.
7
Reverse transcriptase mutations in sequential HIV-1 isolates in a patient with AIDS.一名艾滋病患者连续分离出的HIV-1毒株中的逆转录酶突变
J Med Virol. 1995 Jul;46(3):238-43. doi: 10.1002/jmv.1890460312.
8
Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT).HIV-1逆转录酶中的多个突变赋予对齐多夫定（AZT）的高水平耐药性。
Science. 1989 Dec 1;246(4934):1155-8. doi: 10.1126/science.2479983.
9
Sequence analysis of reverse transcriptase genes of zidovudine (AZT)-resistant and -sensitive human immunodeficiency virus type 1 strains.齐多夫定（AZT）耐药和敏感的1型人类免疫缺陷病毒株逆转录酶基因的序列分析。
J Gen Virol. 1993 Feb;74 ( Pt 2):223-8. doi: 10.1099/0022-1317-74-2-223.
10
pol mutations conferring zidovudine and didanosine resistance with different effects in vitro yield multiply resistant human immunodeficiency virus type 1 isolates in vivo.赋予齐多夫定和去羟肌苷耐药性且在体外具有不同效应的pol突变，在体内产生多重耐药的1型人类免疫缺陷病毒分离株。
Antimicrob Agents Chemother. 1993 Jul;37(7):1480-7. doi: 10.1128/AAC.37.7.1480.

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J Virol. 2004 Jan;78(2):603-11. doi: 10.1128/jvi.78.2.603-611.2004.
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J Virol. 2000 Dec;74(23):10958-64. doi: 10.1128/jvi.74.23.10958-10964.2000.
6
Convergent evolution of reverse transcriptase (RT) genes of human immunodeficiency virus type 1 subtypes E and B following nucleoside analogue RT inhibitor therapies.核苷类似物逆转录酶抑制剂治疗后，人类免疫缺陷病毒1型E亚型和B亚型逆转录酶（RT）基因的趋同进化。
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Use of multiple competitors for quantification of human immunodeficiency virus type 1 RNA in plasma.使用多种竞争物对血浆中1型人类免疫缺陷病毒RNA进行定量分析。
J Clin Microbiol. 1998 Jul;36(7):1864-70. doi: 10.1128/JCM.36.7.1864-1870.1998.
8
Genotypic changes in human immunodeficiency virus type 1 associated with loss of suppression of plasma viral RNA levels in subjects treated with ritonavir (Norvir) monotherapy.在接受利托那韦（诺韦）单一疗法治疗的受试者中，与血浆病毒RNA水平抑制作用丧失相关的1型人类免疫缺陷病毒的基因型变化。
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9
Relative replicative fitness of zidovudine-resistant human immunodeficiency virus type 1 isolates in vitro.齐多夫定耐药的1型人类免疫缺陷病毒分离株在体外的相对复制适应性
J Virol. 1998 May;72(5):3773-8. doi: 10.1128/JVI.72.5.3773-3778.1998.
10
Switch to unusual amino acids at codon 215 of the human immunodeficiency virus type 1 reverse transcriptase gene in seroconvertors infected with zidovudine-resistant variants.在感染齐多夫定耐药变异株的血清转化者中，人类免疫缺陷病毒1型逆转录酶基因密码子215处出现不寻常氨基酸的转换。
J Virol. 1998 May;72(5):3520-3. doi: 10.1128/JVI.72.5.3520-3523.1998.

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The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial.叠氮胸苷（AZT）治疗艾滋病及艾滋病相关综合征患者的疗效。一项双盲、安慰剂对照试验。
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Analysis of the V3 loop in neutralization-resistant human immunodeficiency virus type 1 variants by direct solid-phase DNA sequencing.通过直接固相DNA测序分析中和抗性1型人类免疫缺陷病毒变体中的V3环
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齐多夫定耐药的1型人类免疫缺陷病毒RNA基因型在治疗后血清中的持续存在。

Persistence of azidothymidine-resistant human immunodeficiency virus type 1 RNA genotypes in posttreatment sera.

作者信息

Albert J, Wahlberg J, Lundeberg J, Cox S, Sandström E, Wahren B, Uhlén M

机构信息

Department of Virology, National Bacteriological Laboratory, Stockholm, Sweden.

出版信息

J Virol. 1992 Sep;66(9):5627-30. doi: 10.1128/JVI.66.9.5627-5630.1992.

DOI:10.1128/JVI.66.9.5627-5630.1992
PMID:1380098
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC289127/
Abstract

The rate of reversion from azidothymidine (zidovudine; AZT) resistance was studied by direct sequencing of human immunodeficiency virus type 1 (HIV-1) virion RNA in sera from four patients who discontinued long-term treatment. Before cessation of treatment, all four patients harbored HIV-1 with multiple mutations reported to confer AZT resistance. In three patients, slow reversions of these mutations starting after 9, 9, and 18 months were detected. The slow reversions indicate that AZT-resistant HIV-1 variants are likely to have an unaltered replicative capacity and pathogenic potential. Furthermore, there were discrepancies between the in vivo RNA sequences and the sequences of virus isolates, indicating that the isolation procedure may select for nonrepresentative virus variants.

摘要

通过对4名停止长期治疗患者血清中的1型人类免疫缺陷病毒（HIV-1）病毒体RNA进行直接测序，研究了从叠氮胸苷（齐多夫定；AZT）耐药性逆转的速率。在停止治疗前，所有4名患者携带的HIV-1都有多个据报道可导致AZT耐药性的突变。在3名患者中，检测到这些突变在9个月、9个月和18个月后开始缓慢逆转。这些缓慢逆转表明，对AZT耐药的HIV-1变体可能具有未改变的复制能力和致病潜力。此外，体内RNA序列与病毒分离株序列之间存在差异，这表明分离程序可能会选择非代表性的病毒变体。