Martin G T, Haddad M G, Cravalho E G, Bowman H F
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge 02139.
IEEE Trans Biomed Eng. 1992 Aug;39(8):836-44. doi: 10.1109/10.148391.
A system for the noninvasive localized, hyperthermia treatment of benign prostatic hyperplasia was investigated. The system uses a microwave transrectal antenna with a water cooled jacket to achieve localized hyperthermia. The purpose of this study is to model the temperature rise in the prostate and in the surrounding tissue during treatment. The SAR distribution for the transrectal probe is measured in a muscle tissue equivalent phantom. The SAR information is used with a finite element solution of the bioheat transfer equation to give the temperature rise during the treatment. Also the finite element solution is further used to determine the effect of the microwave power, the cooling fluid temperature and the blood perfusion on the tissue temperature rise. The results of the solution are compared to temperature measurements in a canine protocol. It was found that the maximum temperature rise in the tissue during treatment is 44 degrees C at a depth of 2 cm from the rectal mucosa.
研究了一种用于良性前列腺增生的非侵入性局部热疗系统。该系统使用带有水冷套的微波经直肠天线来实现局部热疗。本研究的目的是对治疗过程中前列腺及周围组织的温度升高进行建模。在肌肉组织等效体模中测量经直肠探头的比吸收率(SAR)分布。将SAR信息与生物热传递方程的有限元解相结合,以得出治疗过程中的温度升高情况。此外,有限元解还进一步用于确定微波功率、冷却液温度和血液灌注对组织温度升高的影响。将该解的结果与犬类实验方案中的温度测量结果进行比较。结果发现,治疗过程中组织内距直肠黏膜2厘米深处的最高温度升高为44摄氏度。