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A comparison of the central actions of prostaglandins A1, E1, E2, F1alpha, and F2alpha in the rat. I. Behavioral, antinociceptive and anticonvulsant actions of intraventricular prostaglandins in the rat.

作者信息

Poddubiuk Z M

出版信息

Psychopharmacology (Berl). 1976 Oct 20;50(1):89-94. doi: 10.1007/BF00634161.

DOI:10.1007/BF00634161
PMID:827769
Abstract

The effect of prostaglandins (PGs) A1, E1, E2, F1alpha, and F2alpha administered intraventricularly at doses of 0.02--4.0 mug/rat were studied in some behavioral, antinociceptive and anticonvulsant tests in rats. Exploratory and locomotor activity were decreased by all PGs except A1 and F2alpha which had no effect on locomotor activity. All PGs studied, except A1, induced hyperthermia and afforded protection in the 'hot-plate' analgesic test and against maximal electro-shock seizures.

摘要

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