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皮肤移植和免疫抑制对小鼠的致癌作用。

Carcinogenic effects of skin transplantation and immunosuppression in mice.

作者信息

Reznik-Schüller H, Kmoch N, Mohr U

出版信息

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Dec 9;87(3):275-80. doi: 10.1007/BF00506500.

DOI:10.1007/BF00506500
PMID:138273
Abstract

C3H and BlD2 mice received skin transplants from an animal of the other strain. Three groups were immunosuppressed for varying periods of time, and with different doses of vinblastine, cyclophosphamide, or azathioprine. Following transplantation, control animals received daily injections of NaCl. All animals developed tumours of lymphoreticular origin, which would indicate that immunosuppression is only a secondary cause for tumor development, with antigenic stimulation being the primary factor.

摘要

C3H 小鼠和 BlD2 小鼠接受了来自另一品系动物的皮肤移植。三组动物接受了不同时间段、不同剂量长春碱、环磷酰胺或硫唑嘌呤的免疫抑制处理。移植后,对照动物每日注射氯化钠。所有动物都长出了淋巴网状系统起源的肿瘤,这表明免疫抑制只是肿瘤发生的次要原因,抗原刺激才是主要因素。

相似文献

1
Carcinogenic effects of skin transplantation and immunosuppression in mice.皮肤移植和免疫抑制对小鼠的致癌作用。
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Dec 9;87(3):275-80. doi: 10.1007/BF00506500.
2
Another look at immunologic surveillance.再看免疫监视。
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3
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5
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Eur J Cancer (1965). 1978 Jun;14(6):653-9. doi: 10.1016/0014-2964(78)90300-6.
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The carcinogenic response in mice to the topical application of propane sultone to the skin.小鼠皮肤局部应用丙烷磺内酯后的致癌反应。
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8
Lack of pluripotent stem cell engraftment in cyclophosphamide-induced tolerance.环磷酰胺诱导的耐受性中多能干细胞植入的缺乏。
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Different role of cyclophosphamide-induced tolerance in heart and skin allograft tolerance.环磷酰胺诱导的耐受性在心脏和皮肤同种异体移植耐受中的不同作用。
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Lymphomagenesis and autoimmunization caused by reactions of T-lymphocytes to incompatible structures of the major histocompatibility complex: a concept of pathogenesis.T淋巴细胞对主要组织相容性复合体不相容结构反应引起的淋巴瘤发生和自身免疫:发病机制的一个概念
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本文引用的文献

1
INDUCTION OF RETICULAR TUMOURS IN MICE BY REPEATED ANTIGENIC STIMULATION.通过反复抗原刺激诱导小鼠网状肿瘤
Acta Unio Int Contra Cancrum. 1963;19:657-9.
2
Malignant lymphomas and plasmacytosis in mice under prolonged immunosuppression and persistent antigenic stimulation.长期免疫抑制和持续抗原刺激下小鼠的恶性淋巴瘤和浆细胞增多症
Transplantation. 1971 Feb;11(2):138-44. doi: 10.1097/00007890-197102000-00006.
3
Azathioprine effects on the development of hamster pouch carcinomas.硫唑嘌呤对仓鼠颊囊癌发生发展的影响。
Arch Pathol. 1971 Mar;91(3):264-70.
4
[Experimental studies on the carcinogenic effects of anticancer chemotherapeutics and immunosuppressive agents].[抗癌化疗药物和免疫抑制剂致癌作用的实验研究]
Arzneimittelforschung. 1970 Oct;20(10):1461-7.
5
Chronic allogeneic disease. II. Development of lymphomas.慢性同种异体疾病。II. 淋巴瘤的发展。
J Exp Med. 1970 Sep 1;132(3):417-39. doi: 10.1084/jem.132.3.417.
6
Primary carcinoma of the cervix appearing in immunosuppressed renal transplant recipient.免疫抑制的肾移植受者中出现的原发性宫颈癌。
Am J Obstet Gynecol. 1971 Feb 15;109(4):663-4. doi: 10.1016/0002-9378(71)90644-2.
7
Malignant tumours following immunosuppressive therapy.免疫抑制治疗后的恶性肿瘤
Can Med Assoc J. 1970 Dec 19;103(13):1362-5.
8
The concept of immunological surveillance.免疫监视的概念。
Prog Exp Tumor Res. 1970;13:1-27. doi: 10.1159/000386035.
9
Cervical dysplasia and cancer developing in women on immunosuppression therapy for renal homotransplantation.
Cancer. 1970 Nov;26(5):1048-52. doi: 10.1002/1097-0142(197011)26:5<1048::aid-cncr2820260512>3.0.co;2-m.
10
Immunosuppression and neoplasia.免疫抑制与肿瘤形成。
Rev Eur Etud Clin Biol. 1970 Jun-Jul;15(6):599-604.