孟买慢性肝病中的丙型肝炎病毒感染

Hepatitis C virus infection in chronic liver disease in Bombay.

作者信息

Amarapurkar D N, Kumar A, Parikh S S, Chopra K B, Murti P, Kalro R H, Desai H G

机构信息

Department of Gastroenterology, B Y L Nair Charitable Hospital, Bombay.

出版信息

Indian J Gastroenterol. 1992 Oct;11(4):162-3.

PMID:1383141

Abstract

To find out the prevalence of antibody of hepatitis C virus (anti-HCV) in patients with chronic liver disease in Bombay, sera from 126 patients (93 men, 33 women; aged 9-70 years, mean 39.7) with chronic liver disease (cirrhosis 103, cirrhosis with hepatocellular carcinoma 3, chronic active hepatitis 20) were tested for HBsAg and anti-HCV antibody. HBsAg positive sera were tested for anti-delta antibody and IgM anti-HBc. All the tests were carried out by ELISA. Of 126 patients, 51 (40.5%) were HBsAg positive, 49 (38.8%) alcoholic and 21 (16.6%) anti-HCV positive. The prevalence of anti-HCV in HBsAg positive, alcoholic and cryptogenic (HBV negative and no alcohol) liver disease patients was 13.7%, 14.7% and 20.5% respectively. Of 21 anti-HCV antibody positive patients, 8 (38%) had received blood transfusions previously. HCV is present in 15-20% of patients with chronic liver disease in Bombay.

摘要

为了查明孟买慢性肝病患者中丙型肝炎病毒抗体（抗-HCV）的流行情况，对126例慢性肝病患者（93例男性，33例女性；年龄9至70岁，平均39.7岁）（103例肝硬化、3例肝硬化合并肝细胞癌、20例慢性活动性肝炎）的血清进行了乙肝表面抗原（HBsAg）和抗-HCV抗体检测。对HBsAg阳性血清检测了抗丁型肝炎病毒抗体和IgM抗-HBc。所有检测均采用酶联免疫吸附测定法（ELISA）。126例患者中，51例（40.5%）HBsAg阳性，49例（38.8%）为酒精性肝病，21例（16.6%）抗-HCV阳性。HBsAg阳性、酒精性和隐源性（HBV阴性且无饮酒史）肝病患者中抗-HCV的流行率分别为13.7%、14.7%和20.5%。21例抗-HCV抗体阳性患者中，8例（38%）既往曾接受过输血。在孟买，15%至20%的慢性肝病患者感染丙型肝炎病毒。