印度尼西亚雅加达急性和慢性肝病患者中丙型肝炎病毒抗体（抗-HCV）的流行情况。

The prevalence of antibody to hepatitis C virus (anti-HCV) in patients with acute and chronic liver diseases in Jakarta, Indonesia.

作者信息

Sulaiman H A, Noer H M, Endardjo S, Hoyaranda E

机构信息

Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta.

出版信息

Gastroenterol Jpn. 1991 Jul;26 Suppl 3:179-83. doi: 10.1007/BF02779294.

DOI:10.1007/BF02779294

PMID:1909263

Abstract

The seroepidemiology of HBV and HCV infections in the patients with acute and chronic liver diseases in Jakarta was investigated. The sera from 141 cases with acute hepatitis, 176 liver cirrhosis and 70 hepatocellular carcinoma (HCC) were examined. Anti-HA IgM, HBsAg, anti-HBc IgM and anti HCV (Ortho) were detected by Elisa method. In acute hepatitis, 83 cases (58.9%) out of 141 cases were hepatitis A and 9 cases (6.4%) hepatitis B. The others were diagnosed non-A, non-B (NANB) hepatitis and anti-HCV in 4 cases (11.8%) out of 34 cases with NANB hepatitis was positive. The low prevalence of anti-HCV in acute NANB hepatitis seems to be due to inadequate date of serum sampling. HBsAg and anti-HCV in liver cirrhosis were positive 36.5% and 73.9% respectively, including 22.7% of double infection. HBsAg and anti-HCV in HCC were 58.6% and 34.2%, including 17.1% of double infection. In 16.7% fo chronic liver disease (liver cirrhosis and HCC), neither HBsAg nor anti-HCV were detected.

摘要

对雅加达急慢性肝病患者的乙肝病毒（HBV）和丙肝病毒（HCV）感染血清流行病学进行了调查。检测了141例急性肝炎、176例肝硬化和70例肝细胞癌（HCC）患者的血清。采用酶联免疫吸附测定（ELISA）法检测抗甲型肝炎病毒（HA）IgM、乙肝表面抗原（HBsAg）、抗乙肝核心抗体IgM（抗-HBc IgM）和抗丙肝病毒（Ortho）。在急性肝炎患者中，141例中有83例（58.9%）为甲型肝炎，9例（6.4%）为乙型肝炎。其他病例诊断为非甲非乙型（NANB）肝炎，34例NANB肝炎患者中有4例（11.8%）抗HCV呈阳性。急性NANB肝炎中抗HCV的低流行率似乎是由于血清采样时间不足所致。肝硬化患者中HBsAg和抗HCV阳性率分别为36.5%和73.9%，包括22.7%的双重感染。HCC患者中HBsAg和抗HCV阳性率分别为58.6%和34.2%，包括17.1%的双重感染。在16.7%的慢性肝病（肝硬化和HCC）患者中，未检测到HBsAg和抗HCV。