伤寒沙门氏菌Vi阴性菌株的实验
Experiments with Vi-negative strains of Salmonella typhi.
作者信息
STANDFAST A F
出版信息
Bull World Health Organ. 1960;23(1):47-52.
Abstract
The immunological properties of a number of strains of Salmonella typhi were tested. One of these strains, although it did not contain the Vi antigen, was able to protect the mice against Vi-positive challenge when used as a vaccine for mice. The finding of a stable Vi-negative strain is important, as many strains, such as the classic O 901, revert to the Vi-positive state on a single mouse passage.Using the Vi-negative organism as challenge in eight assays of the vaccines used in the Yugoslav field studies at Osijek, the phenolized vaccine was shown to be about 10 times more potent than the alcoholized vaccine. Further laboratory tests in conjunction with field trials will be necessary to show if these results are significant.
摘要
对若干伤寒沙门氏菌菌株的免疫特性进行了测试。其中一个菌株，尽管它不含有Vi抗原，但当用作小鼠疫苗时，能够保护小鼠免受Vi阳性菌株的攻击。发现一种稳定的Vi阴性菌株很重要，因为许多菌株，如经典的O 901，在小鼠体内传代一次就会恢复为Vi阳性状态。在奥西耶克进行的南斯拉夫现场研究中，使用Vi阴性菌株对八种疫苗进行攻击试验，结果表明酚化疫苗的效力比醇化疫苗高约10倍。是否这些结果具有显著性，还需要进一步的实验室测试并结合现场试验来证明。
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