苏联对五种伤寒疫苗进行的对照现场试验和实验室研究。
A controlled field trial and laboratory study of five typhoid vaccines in the USSR.
作者信息
Hejfec L B, Salmin L V, Lejtman M Z, Kuz'minova M L, Vasil'eva A V, Levina L A, Bencianova T G, Pavlova E A, Antonova A A
出版信息
Bull World Health Organ. 1966;34(3):321-39.
Abstract
A controlled field trial of typhoid vaccines was carried out in the USSR in 1962. It was the fifth and last of a series. Five preparations were tested, the most effective being a heat-killed divalent vaccine prepared from aerated broth culture. The results of a laboratory study of the vaccines were not in complete agreement with the data from the field trial. No correlation was found between the effectiveness of vaccines and the data from laboratory tests as to their potency, and the authors suggest that differences in effectiveness may be due to varying degrees of damage to biological components during the different production processes. The effectiveness is also sensitive to dosage.
摘要
1962年，苏联进行了一项伤寒疫苗的对照现场试验。这是该系列试验中的第五次也是最后一次。共测试了五种制剂，其中最有效的是由通气肉汤培养物制备的热灭活二价疫苗。疫苗的实验室研究结果与现场试验数据并不完全一致。未发现疫苗效力与实验室测试数据之间存在相关性，作者认为效力差异可能是由于不同生产过程中生物成分受损程度不同所致。效力对剂量也很敏感。
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