Ogden G R, Chisholm D M, Leigh I M, Lane E B
Department of Dental Surgery, Dundee University, Scotland.
J Oral Pathol Med. 1992 Sep;21(8):353-7. doi: 10.1111/j.1600-0714.1992.tb01364.x.
In dyskeratosis congenita, the hyperkeratotic lesions affecting the mucous membranes have a propensity to undergo malignant change. Unfortunately there is presently no reliable method for predicting such an outcome. Oral mucosal biopsies were obtained from a case of dyskeratosis congenita and keratin expression identified using a panel of antikeratin antibodies. Marked changes were found from keratin profiles established for normal oral mucosa. In particular coexpression of three separate type 1 keratins (K16, K10 and K13) were observed in the ventral tongue lesion. The keratin pattern found in the tissue biopsies examined is suggestive of an unusually immature or disturbed state of tissue differentiation, and as such may be indicative of future malignant change.
在先天性角化不良中，影响黏膜的角化过度性病变易于发生恶变。不幸的是，目前尚无可靠方法预测这种结果。从一例先天性角化不良患者获取口腔黏膜活检标本，并用一组抗角蛋白抗体鉴定角蛋白表达。发现与正常口腔黏膜所建立的角蛋白谱有明显变化。特别是在舌腹病变中观察到三种不同的Ⅰ型角蛋白（K16、K10和K13）共表达。在所检查的组织活检中发现的角蛋白模式提示组织分化处于异常不成熟或紊乱状态，因此可能预示未来会发生恶变。
