Ogden G R, Lane D P, Chisholm D M
Department of Dental Surgery, University of Dundee Dental Hospital and School.
J Clin Pathol. 1993 Feb;46(2):169-70. doi: 10.1136/jcp.46.2.169.
As p53 expression has been associated with malignant disease its presence was assessed in biopsy specimens from dorsal lingual hyperkeratosis, taken over a five year period. p53 expression, using CM1, was assessed using a standard immunoperoxidase technique. p53 was not identified in the first biopsy specimen in 1986 but was identified in all subsequent ones. Only in the latest biopsy specimen was there evidence for dysplasia in haematoxylin and eosin stained sections. It is suggested that p53 expression may be a reliable marker for predicting premalignant change in keratoses occurring in dyskeratosis congenita.
由于p53表达与恶性疾病相关，因此在五年期间采集的舌背角化病活检标本中评估了其存在情况。使用标准免疫过氧化物酶技术，采用CM1评估p53表达。1986年的第一份活检标本中未发现p53，但在随后所有标本中均有发现。仅在最新的活检标本中，苏木精和伊红染色切片中有发育异常的证据。提示p53表达可能是预测先天性角化不良中角化病恶变前变化的可靠标志物。
