Hukkanen M, Konttinen Y T, Rees R G, Gibson S J, Santavirta S, Polak J M
Department of Histochemistry, Royal Postgraduate Medical School, London, UK.
J Rheumatol. 1992 Aug;19(8):1252-9.
Mechanical stress causes remodelling of bone, a transformation of bone structure by physical forces through an unknown mechanism. Inflammation also affects bone structure, through altered use and the production of various inflammatory mediators. The peripheral nervous system may play both a sensory and an efferent role in the mechanical and inflammatory influences on bone structure. We studied the occurrence of substance P and calcitonin gene related peptide (CGRP) containing nerves in periosteal tissue, bone marrow, diaphysis and epiphysis of the ankle and knee joints of healthy and adjuvant arthritic rats. In arthritic animals, only ankle joints were affected by the inflammation. The periosteum was richly innervated both in healthy and arthritic animals. In arthritic rats few nerve fibers penetrated the woven, callous bone underlying the periosteum. Also bone marrow contained substance P and CGRP immunoreactive nerves in normal bone, whereas the hypercellular bone marrow of arthritic rats showed a decrease in the density of substance P and CGRP containing fibers. Epiphysis had a dense innervation compared to diaphysis. In contrast to large erosions, small peripheral erosions contained some CGRP immunoreactive fibers, perhaps as a sign of attempts of reactive repair. Our results suggest a local delivery system of potent peptide regulatory factors in bone, a system also affected by the pathophysiology of arthritis.
机械应力会导致骨骼重塑，即通过未知机制由物理力引起的骨结构转变。炎症也会通过改变使用方式和产生各种炎症介质来影响骨结构。外周神经系统可能在对骨结构的机械和炎症影响中发挥感觉和传出作用。我们研究了健康大鼠和佐剂性关节炎大鼠的踝关节和膝关节的骨膜组织、骨髓、骨干和骨骺中含P物质和降钙素基因相关肽（CGRP）的神经的发生情况。在患关节炎的动物中，只有踝关节受到炎症影响。在健康和患关节炎的动物中，骨膜都有丰富的神经支配。在患关节炎的大鼠中，很少有神经纤维穿透骨膜下方的编织状、骨痂样骨。正常骨的骨髓中也含有P物质和CGRP免疫反应性神经，而患关节炎大鼠的细胞增多的骨髓中含P物质和CGRP的纤维密度降低。与骨干相比，骨骺有密集的神经支配。与大的侵蚀不同，小的周边侵蚀含有一些CGRP免疫反应性纤维，这可能是反应性修复尝试的一个迹象。我们的结果表明骨中存在一个有效的肽调节因子局部递送系统，该系统也受关节炎病理生理学的影响。
