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Potentiation of sodium chromate(VI)-induced chromosomal aberrations and mutation by vitamin B2 in Chinese hamster V79 cells.

作者信息

Sugiyama M, Tsuzuki K, Lin X, Costa M

机构信息

Department of Medical Biochemistry, Kurume University School of Medicine, Japan.

出版信息

Mutat Res. 1992 Nov;283(3):211-4. doi: 10.1016/0165-7992(92)90109-u.

DOI:10.1016/0165-7992(92)90109-u
PMID:1383790
Abstract

The effect of vitamin B2, which is capable of reducing chromium(VI) to chromium(V), on chromosomal aberrations and mutation caused by Na2CrO4 was investigated in Chinese hamster V79 cells. Pretreatment with 200 microM vitamin B2 (riboflavin) for 24 h prior to exposure to Na2CrO4 (2.5-5 microM) resulted in an increase of metal-induced chromosomal aberrations and mutation at the HGPRT locus. These and other previous studies suggest that vitamin B2 enhances the clastogenic and mutagenic action of chromate compounds, through its ability to directly reduce chromium(VI) in cells.

摘要

相似文献

1
Potentiation of sodium chromate(VI)-induced chromosomal aberrations and mutation by vitamin B2 in Chinese hamster V79 cells.
Mutat Res. 1992 Nov;283(3):211-4. doi: 10.1016/0165-7992(92)90109-u.
2
Influence of vitamin B2 on formation of chromium(V), alkali-labile sites, and lethality of sodium chromate(VI) in Chinese hamster V-79 cells.维生素B2对中国仓鼠V-79细胞中铬（V）的形成、碱不稳定位点以及铬酸钠（VI）致死性的影响。
Cancer Res. 1989 Nov 15;49(22):6180-4.
3
Protective effect of vitamin E against chromosomal aberrations and mutation induced by sodium chromate in Chinese hamster V79 cells.维生素E对铬酸钠诱导的中国仓鼠V79细胞染色体畸变和突变的保护作用。
Mutat Res. 1991 May;260(1):19-23. doi: 10.1016/0165-1218(91)90076-x.
4
Vitamin B2-enhancement of sodium chromate (VI)--Induced DNA single strand breaks: ESR study of the action of vitamin B2.维生素B2增强铬酸钠（VI）诱导的DNA单链断裂：维生素B2作用的电子自旋共振研究
Biochem Biophys Res Commun. 1989 Mar 31;159(3):1080-5. doi: 10.1016/0006-291x(89)92219-5.
5
Differential mutagenic response at the HGPRT locus in V79 and CHO Chinese hamster cells after treatment with chromate.用铬酸盐处理后，V79和中国仓鼠卵巢（CHO）细胞在次黄嘌呤-鸟嘌呤磷酸核糖转移酶（HGPRT）位点的差异诱变反应。
Mutat Res. 1983 Dec;122(3-4):361-5. doi: 10.1016/0165-7992(83)90020-9.
6
Effect of vitamin E on survival, glutathione reductase and formation of chromium (V) in Chinese hamster V-79 cells treated with sodium chromate (VI).维生素E对经铬（VI）酸钠处理的中国仓鼠V - 79细胞的存活率、谷胱甘肽还原酶及铬（V）形成的影响。
Carcinogenesis. 1989 Apr;10(4):737-41. doi: 10.1093/carcin/10.4.737.
7
Cytotoxic, and mutagenic effects at the HGPRT locus of 4CMB in V79 Chinese hamster cells.4-氯-3-甲基苯硼酸（4CMB）对V79中国仓鼠细胞次黄嘌呤鸟嘌呤磷酸核糖转移酶（HGPRT）位点的细胞毒性和诱变作用。
Mutat Res. 1982 Jan-Feb;100(1-4):235-8. doi: 10.1016/0165-1218(82)90052-0.
8
Effects of vitamin E, vitamin B2 and selenite on DNA single strand breaks induced by sodium chromate (VI).维生素E、维生素B2和亚硒酸盐对铬（VI）酸钠诱导的DNA单链断裂的影响。
Cancer Lett. 1987 Dec;38(1-2):1-7. doi: 10.1016/0304-3835(87)90193-5.
9
Effects of vitamins on chromium(VI)-induced damage.维生素对六价铬诱导损伤的影响。
Environ Health Perspect. 1991 May;92:63-70. doi: 10.1289/ehp.919263.
10
Effect of ascorbic acid on DNA damage, cytotoxicity, glutathione reductase, and formation of paramagnetic chromium in Chinese hamster V-79 cells treated with sodium chromate(VI).抗坏血酸对用铬（VI）酸钠处理的中国仓鼠V - 79细胞中DNA损伤、细胞毒性、谷胱甘肽还原酶及顺磁性铬形成的影响。
J Biol Chem. 1991 Feb 25;266(6):3383-6.

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2
Chromium genotoxicity: A double-edged sword.铬的遗传毒性：一把双刃剑。
Chem Biol Interact. 2010 Nov 5;188(2):276-88. doi: 10.1016/j.cbi.2010.04.018. Epub 2010 Apr 27.
3
Homologous recombination repair protects against particulate chromate-induced chromosome instability in Chinese hamster cells.同源重组修复可防止颗粒状铬酸盐诱导中国仓鼠细胞的染色体不稳定。
Mutat Res. 2007 Dec 1;625(1-2):145-54. doi: 10.1016/j.mrfmmm.2007.06.003. Epub 2007 Jun 19.
4
Role of paramagnetic chromium in chromium(VI)-induced damage in cultured mammalian cells.顺磁性铬在六价铬诱导的培养哺乳动物细胞损伤中的作用。
Environ Health Perspect. 1994 Sep;102 Suppl 3(Suppl 3):31-3. doi: 10.1289/ehp.94102s331.