Sugiyama M, Lin X H, Costa M
Department of Medical Biochemistry, Kurume University School of Medicine, Japan.
Mutat Res. 1991 May;260(1):19-23. doi: 10.1016/0165-1218(91)90076-x.
The effect of vitamin E on chromosomal aberrations and mutation caused by Na2CrO4 was investigated in Chinese hamster V79 cells. Pretreatment with 25 microM alpha-tocopherol succinate (vitamin E) for 24 h prior to chromate exposure (2.5-5 microM) resulted in a decrease of metal-induced chromosomal aberrations. Na2CrO4 (2.5-7.5 microM) induced mutations at the HGPRT locus, but only within a very limited concentration range. This mutagenic response could also be suppressed by pretreatment with vitamin E. These results suggest that vitamin E can protect cells from the clastogenic and mutagenic action of chromate compounds, possibly through its ability to scavenge chromium(V) and/or free radicals.
在中国仓鼠V79细胞中研究了维生素E对铬酸钠引起的染色体畸变和突变的影响。在铬酸盐暴露（2.5 - 5 microM）前24小时用25 microM琥珀酸α-生育酚（维生素E）预处理，导致金属诱导的染色体畸变减少。铬酸钠（2.5 - 7.5 microM）在HGPRT位点诱导突变，但仅在非常有限的浓度范围内。这种诱变反应也可以通过维生素E预处理来抑制。这些结果表明，维生素E可能通过清除铬（V）和/或自由基的能力来保护细胞免受铬酸盐化合物的致断裂和诱变作用。
