胶质瘤的缺失图谱表明在染色体10q上一个17厘摩区间内存在两个候选肿瘤抑制基因的小区域。
Deletion mapping of gliomas suggest the presence of two small regions for candidate tumor-suppressor genes in a 17-cM interval on chromosome 10q.
作者信息
Albarosa R, Colombo B M, Roz L, Magnani I, Pollo B, Cirenei N, Giani C, Conti A M, DiDonato S, Finocchiaro G
机构信息
Department of Biochemistry, Istituto Nazionale Neurologico C. Besta, Milan, Italy.
出版信息
Am J Hum Genet. 1996 Jun;58(6):1260-7.
The loss of genetic material on chromosome 10q is frequent in different tumors and particularly in malignant gliomas. We analyzed 90 of these tumors and found loss of heterozygosity (LOH) in >90% of the informative loci in glioblastoma multiforme (GBM). Initial studies restricted the common LOH region to 10q24-qter. Subsequently, the study of a pediatric GBM suggested D10S221 and D10S209, respectively, as centromeric and telomeric markers of a 4-cM LOH region. It is interesting to note that, in one subset of cells from this tumor, locus D10S209 seems involved in the allelic imbalance of a larger region, with D10S214 as telomeric marker. This 17-cM region contains the D10S587-D10S216 interval of common deletion recently defined on another set of gliomas.
10号染色体长臂（10q）上遗传物质的缺失在不同肿瘤中很常见，尤其是在恶性胶质瘤中。我们分析了90例此类肿瘤，发现多形性胶质母细胞瘤（GBM）中>90%的信息位点存在杂合性缺失（LOH）。最初的研究将常见的LOH区域限定在10q24 - qter。随后，一项儿童GBM研究分别提出D10S221和D10S209作为一个4厘摩（cM）LOH区域的着丝粒和端粒标记。值得注意的是，在该肿瘤的一个细胞亚群中，位点D10S209似乎参与了一个更大区域的等位基因失衡，以D10S214作为端粒标记。这个17 cM的区域包含了最近在另一组胶质瘤中定义的常见缺失的D10S587 - D10S216区间。
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