Villa I, Guidobono F, Netti C, Pecile A, Giovanazzi S, Nicosia S
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Italy.
Neuroreport. 1992 Jul;3(7):601-4. doi: 10.1097/00001756-199207000-00014.
In order to investigate the effects of ageing on the cerebral receptors for calcitonin (CT), we used an in vitro autoradiographic method to study the distribution of the binding sites for eel CT (eCT) in young and old rat brain. The inhibitory action of eCT on adenylyl-cyclase (AC) activity upon isolated brain cell membranes was also evaluated. The results show area-specific reduction of binding particularly in the hypothalamus and pons medulla of the old rat. The inhibitory action of eCT on AC activity was significantly reduced in the same areas, whereas in the striatum and mesencephalon no changes were observed. The parallel decrease of binding of eCT and of the inhibitory action of eCT on AC in ageing may represent a functional decline of neuronal activities during ageing.
为了研究衰老对大脑降钙素（CT）受体的影响，我们采用体外放射自显影法研究了年轻和老年大鼠脑中鳗鱼降钙素（eCT）结合位点的分布。我们还评估了eCT对离体脑细胞膜上腺苷酸环化酶（AC）活性的抑制作用。结果显示，结合有区域特异性减少，尤其在老年大鼠的下丘脑和脑桥延髓。eCT对AC活性的抑制作用在相同区域显著降低，而在纹状体和中脑未观察到变化。衰老过程中eCT结合以及eCT对AC抑制作用的平行下降可能代表衰老过程中神经元活动的功能衰退。
