Goltzman D, Mitchell J
Science. 1985 Mar 15;227(4692):1343-5. doi: 10.1126/science.2983422.
Discrete receptor sites for calcitonin (CT) and calcitonin gene-related peptide (CGRP) were found in the nervous system and in peripheral tissues. Each peptide was capable of cross-reacting with the specific receptor of the other. In contrast to CT receptors, CGRP receptors were not linked to adenylate cyclase. However, CGRP could stimulate adenylate cyclase in CT target tissues apparently by interacting with CT receptors. The relative abilities of CGRP and mammalian CT to inhibit CT binding suggest that CGRP could serve as an endogenous ligand for CT receptors in the central nervous system.
在神经系统和外周组织中发现了降钙素（CT）和降钙素基因相关肽（CGRP）的离散受体位点。每种肽都能够与另一种肽的特异性受体发生交叉反应。与CT受体不同，CGRP受体不与腺苷酸环化酶相连。然而，CGRP显然可以通过与CT受体相互作用来刺激CT靶组织中的腺苷酸环化酶。CGRP和哺乳动物CT抑制CT结合的相对能力表明，CGRP可能作为中枢神经系统中CT受体的内源性配体。
