Nicosia S, Guidobono F, Musanti M, Pecile A
Life Sci. 1986 Dec 8;39(23):2253-62. doi: 10.1016/0024-3205(86)90404-2.
We have investigated the effect of calcitonin (CT) on adenylate cyclase in membranes from different rat brain areas. Salmon calcitonin (sCT) dose-dependently inhibited the enzyme activity in midbrain, hypothalamus, medulla, pons and caudate nucleus, but was ineffective in adenohypophysis. The inhibitory effect was enhanced by GTP. Comparison of calcitonins of different origin indicated that sCT was the most potent in inhibiting the enzyme in hypothalamic membranes, eel CT (eCT) was slightly less potent, and human CT (hCT) was ineffective. Chronic I.C.V. pretreatment with sCT did not modify the subsequent in vitro sensitivity of adenylate cyclase to sCT. It is concluded that some of CNS actions of CT might involve modulation of intracellular cAMP levels.
我们研究了降钙素（CT）对来自不同大鼠脑区的膜中腺苷酸环化酶的作用。鲑鱼降钙素（sCT）剂量依赖性地抑制中脑、下丘脑、延髓、脑桥和尾状核中的酶活性，但对腺垂体无效。GTP可增强这种抑制作用。不同来源降钙素的比较表明，sCT在下丘脑膜中抑制该酶的作用最强，鳗鱼CT（eCT）的作用稍弱，而人CT（hCT）则无效。慢性脑室内给予sCT预处理并未改变随后腺苷酸环化酶对sCT的体外敏感性。结论是，CT的某些中枢神经系统作用可能涉及细胞内cAMP水平的调节。
