Ashmarin I P, Gurskaia I E, Guseva A A, Lelekova T V, Sanzhieva L Ch, Chepurnov S A, Chepurnova N E, Shimanko I I, Limarev V M, Gavriushov V V
Vestn Ross Akad Med Nauk. 1992(6):40-4.
In addition to the well-known activities of TRH (stimulation of respiration, antidepressant action, increase of motility, antishock action, therapeutic effects against ataxia, and so forth), some new properties were established. TRH was found (1) to stimulate the contractility of lymph vessels in ultra-low doses and to be useful in the treatment of acute pancreatitis; (2) to normalize cerebral circulation in rats and neonates after asphyxia; (3) to improve the electrophysiological parameters of the retina and pigmented epithelium in rats and man, to exert a long-term positive influence on the health status of patients suffering from senile retinal macular dystrophy; (4) to potentiate the analgesic effect of low doses of morphine in a definite range of doses (analog PR-546). It is of paramount importance that most of the indicated activities of TRH may hold promise for clinical application.
除了众所周知的促甲状腺激素释放激素（TRH）的活性（刺激呼吸、抗抑郁作用、增加运动性、抗休克作用、治疗共济失调等）外，还发现了一些新特性。已发现TRH：（1）在超低剂量下刺激淋巴管的收缩性，对治疗急性胰腺炎有用；（2）使窒息后的大鼠和新生儿的脑循环正常化；（3）改善大鼠和人类视网膜及色素上皮的电生理参数，对患有老年性视网膜黄斑营养不良的患者的健康状况产生长期积极影响；（4）在一定剂量范围内增强低剂量吗啡的镇痛作用（类似物PR - 546）。最重要的是，TRH的大多数上述活性可能具有临床应用前景。
