Shimanko I I, Limarev V M, Ashmarin I P, Lelekova T V, Sanzhieva L Ts
Khirurgiia (Mosk). 1992 Jan(1):64-6.
Experiments were conducted to study the modulating effect of thyrotropin-releasing hormone, (TRH) on the contractility of lymphatic vessels of the rat mesenterium. Later, TRH was applied in the clinic in the treatment of edematous and destructive forms of acute pancreatitis in 15 patients. as a result, echoscopy showed diminished edema of the pancreas, amylasemia decreased, the concentration of middle mass molecules in the blood reduced and their transport in the urine intensified. The agent was infused into the veins and into the lymphatic vessels, which allowed its dose to be reduced by half.
进行实验以研究促甲状腺激素释放激素（TRH）对大鼠肠系膜淋巴管收缩性的调节作用。后来，TRH应用于临床，治疗15例急性胰腺炎水肿型和坏死型患者。结果，超声检查显示胰腺水肿减轻，血淀粉酶降低，血液中中分子物质浓度降低，其尿中排泄增加。该药物经静脉和淋巴管输注，使药物剂量减半。
