Simşek U, Kutlu S, Yavaşçaouğlu I, Oktay B, Ozyurt M
Department of Urology, Uludağ University, Bursa, Turkey.
Eur Urol. 1992;21 Suppl 1:111-4. doi: 10.1159/000474906.
The seasonal pattern of prostatic acid phosphatase (PAP) and prostate specific antigen (PSA) in nonmalignant males was investigated. Serum levels were measured in 1,540 men during a 3-year period with radioimmunoassay methods using monoclonal antibody techniques. All of the tested individuals were free of prostatic malignancy. During each of the 3 years, PAP ans PSA showed a rise, especially in spring. The mean PSA level in spring showed a statistically important difference when compared with winter, fall and summer mean levels (p less than 0.05). However, no significant difference of PAP levels was estimated seasonally in the 3 years, which shows that an important marker of prostatic cancer can vary with seasons.
研究了非恶性男性中前列腺酸性磷酸酶（PAP）和前列腺特异性抗原（PSA）的季节性模式。在3年期间，使用单克隆抗体技术通过放射免疫测定法测量了1540名男性的血清水平。所有受试个体均无前列腺恶性肿瘤。在这3年中的每一年，PAP和PSA均呈现上升趋势，尤其是在春季。与冬季、秋季和夏季的平均水平相比，春季的平均PSA水平显示出统计学上的显著差异（p<0.05）。然而，在这3年中，PAP水平在季节上没有估计出显著差异，这表明前列腺癌的一个重要标志物可能随季节变化。
