ALLEN W P
J Exp Med. 1962 Feb 1;115(2):411-20. doi: 10.1084/jem.115.2.411.
Acquired resistance to fully virulent strains of P. tularensis was passively transferred to normal mice by viable spleen cells or peritoneal leucocytes from donors that recovered from infection with an attenuated strain of P. tularensis. This passively transferred resistance was reflected in survival or delayed death after challenge of the recipients. The degree of passively transferred resistance was dependent upon the immune status of the donors and the number of viable immune cells transferred. There were indications that this resistance persisted only as long as the transferred tissues were compatible with the tissues of the recipient. The results support the hypothesis that immunity of mice against fully virulent strains of P. tularensis is associated with an altered state of the tissues.
从感染减毒土拉弗朗西斯菌菌株后康复的供体中获取的存活脾细胞或腹膜白细胞，将对完全有毒力的土拉弗朗西斯菌菌株的获得性抗性被动转移至正常小鼠。这种被动转移的抗性表现为受体受到攻击后的存活或延迟死亡。被动转移抗性的程度取决于供体的免疫状态以及转移的存活免疫细胞数量。有迹象表明，这种抗性仅在转移的组织与受体组织相容时才会持续存在。这些结果支持了这样一种假说，即小鼠对完全有毒力的土拉弗朗西斯菌菌株的免疫与组织状态的改变有关。
