Vidal-Puig A, Muñoz-Torres M, Escobar-Jiménez F, Ruiz Requena M E, Garcia-Calvente C, Torres-Vela E
Department of Internal Medicine I, University of Granada Hospital, Spain.
J Steroid Biochem Mol Biol. 1992 Jul;42(6):607-11. doi: 10.1016/0960-0760(92)90451-n.
This study was designed to investigate the most important factors affecting serum concentrations of sex hormone-binding globulin (SHBG) in women with hirsutism. We compared endocrine profiles based on biochemical measurements of LH, FSH, oestradiol, testosterone (T), prolactin, 17-hydroxy-progesterone, dehydroepiandrosterone sulphate (DHEAS), SHBG, cortisol and insulin in the follicular phase in 32 healthy women and 52 patients. The study group was subdivided according to SHBG levels into Group A (low level) and Group B (high level). Significant differences between Groups A and B were found in DHEAS and T levels, but not in body mass index or insulinaemia. There was a relationship between DHEAS and SHBG levels (r = 0.51) and between T and SHBG (r = 0.31). We conclude that DHEAS may be a significant modulator of SHBG in the female hirsute patient, an observation seldom mentioned in previous reports.
本研究旨在调查影响多毛症女性血清性激素结合球蛋白（SHBG）浓度的最重要因素。我们基于32名健康女性和52名患者在卵泡期的促黄体生成素（LH）、促卵泡激素（FSH）、雌二醇、睾酮（T）、催乳素、17-羟孕酮、硫酸脱氢表雄酮（DHEAS）、SHBG、皮质醇和胰岛素的生化测量结果，比较了内分泌特征。研究组根据SHBG水平分为A组（低水平）和B组（高水平）。A组和B组在DHEAS和T水平上存在显著差异，但在体重指数或胰岛素血症方面无显著差异。DHEAS与SHBG水平之间存在相关性（r = 0.51），T与SHBG之间也存在相关性（r = 0.31）。我们得出结论，DHEAS可能是女性多毛症患者SHBG的重要调节因子，这一观察结果在以往报告中很少提及。
