一个重新定义亨廷顿舞蹈病区域的重组事件。
A recombination event that redefines the Huntington disease region.
作者信息
Snell R G, Thompson L M, Tagle D A, Holloway T L, Barnes G, Harley H G, Sandkuijl L A, MacDonald M E, Collins F S, Gusella J F
机构信息
Department of Medical Genetics, University of Wales College of Medicine, Cardiff, United Kingdom.
出版信息
Am J Hum Genet. 1992 Aug;51(2):357-62.
Abstract
We report both a recombination event that places the Huntington disease gene proximal to the marker D4S98 and an extended linkage-disequilibrium study that uses this marker and confirms the existence of disequilibrium between it and the HD locus. We also report the cloning of other sequences in the region around D4S98, including a new polymorphic marker R10 and conserved sequences that identify a gene in the region of interest.
摘要
我们报告了一个重组事件，该事件将亨廷顿舞蹈病基因定位到标记D4S98近端，还报告了一项扩展的连锁不平衡研究，该研究使用此标记并证实了它与HD基因座之间存在不平衡。我们还报告了D4S98周围区域其他序列的克隆情况，包括一个新的多态性标记R10以及确定了感兴趣区域内一个基因的保守序列。
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A recombination event that redefines the Huntington disease region.一个重新定义亨廷顿舞蹈病区域的重组事件。
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引用本文的文献
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Defining the location of the Huntington disease gene.确定亨廷顿舞蹈症基因的位置。
Am J Hum Genet. 1993 Jan;52(1):214.
2
Significant linkage disequilibrium between the Huntington's disease locus and markers at loci D4S10, D4S95, and D4S111 in Northern Ireland.在北爱尔兰，亨廷顿舞蹈症基因座与位于D4S10、D4S95和D4S111基因座的标记之间存在显著的连锁不平衡。
J Med Genet. 1993 Dec;30(12):1018-9. doi: 10.1136/jmg.30.12.1018.
3
Allele frequencies and linkage disequilibrium of polymorphic DNA markers of the Huntington disease region in the German population.德国人群中亨廷顿病区域多态性DNA标记的等位基因频率及连锁不平衡
Hum Genet. 1993 Dec;92(6):593-7. doi: 10.1007/BF00420945.
本文引用的文献
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A polymorphic DNA marker genetically linked to Huntington's disease.一种与亨廷顿舞蹈症基因连锁的多态性DNA标记。
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Selective transfer of individual human chromosomes to recipient cells.将人类个体染色体选择性转移至受体细胞。
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A highly polymorphic locus very tightly linked to the Huntington's disease gene.一个与亨廷顿舞蹈症基因紧密连锁的高度多态性位点。
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Recombination events suggest potential sites for the Huntington's disease gene.重组事件提示了亨廷顿舞蹈症基因的潜在位点。
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