一种与亨廷顿舞蹈症基因连锁的多态性DNA标记。
A polymorphic DNA marker genetically linked to Huntington's disease.
作者信息
Gusella J F, Wexler N S, Conneally P M, Naylor S L, Anderson M A, Tanzi R E, Watkins P C, Ottina K, Wallace M R, Sakaguchi A Y
出版信息
Nature. 1983;306(5940):234-8. doi: 10.1038/306234a0.
DOI:10.1038/306234a0
PMID:6316146
Abstract
Family studies show that the Huntington's disease gene is linked to a polymorphic DNA marker that maps to human chromosome 4. The chromosomal localization of the Huntington's disease gene is the first step in using recombinant DNA technology to identify the primary genetic defect in this disorder.
摘要
家族研究表明，亨廷顿舞蹈症基因与一个定位在人类第4号染色体上的多态性DNA标记有关。确定亨廷顿舞蹈症基因的染色体定位，是运用重组DNA技术来识别该疾病主要基因缺陷的第一步。
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