Li He, Pan Xueting, Wang Tianyun, Fan Zhenlin, Wang Hai, Ren Wenjie
Institutes of Health Central Plain, Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical University Xinxiang 453003 China.
CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China.
Small Sci. 2024 Jan 8;4(3):2300255. doi: 10.1002/smsc.202300255. eCollection 2024 Mar.
Tissue damage often causes considerable suffering to patients due to slow recovery and poor prognosis. The use of electroactive materials to deliver biophysical signals plays a key role in regulating tissue regeneration processes. Among these materials, piezoelectric materials have unique electromechanical conversion capabilities, making them suitable for use as cell scaffolds. They can deform and emit electrical signals in response to external stimuli, thereby regulating cell proliferation and differentiation. In this review, recent advances are presented in piezoelectric materials as physical signaling mediators that regulate cell differentiation. The basic mechanisms, classification of these materials, and their different applications in tissue regeneration are described. Finally, a comprehensive discussion of current challenges and prospects in the field is provided. Together, existing experimental results basically show that piezoelectric materials can improve the process and effect of tissue repair, providing new technical options for the development of tissue engineering in the future.
由于恢复缓慢和预后不良，组织损伤常常给患者带来相当大的痛苦。使用电活性材料传递生物物理信号在调节组织再生过程中起着关键作用。在这些材料中，压电材料具有独特的机电转换能力，使其适合用作细胞支架。它们可以响应外部刺激而变形并发出电信号，从而调节细胞增殖和分化。在这篇综述中，介绍了压电材料作为调节细胞分化的物理信号介质的最新进展。描述了这些材料的基本机制、分类及其在组织再生中的不同应用。最后，对该领域当前的挑战和前景进行了全面讨论。总体而言，现有实验结果基本表明，压电材料可以改善组织修复的过程和效果，为未来组织工程的发展提供新的技术选择。
