Jean-Pierre H, Rivière M, Darbas H, Boyer G
Laboratoire de Bactériologie, Hôpital Arnaud de Villeneuve, Montpellier, France.
Pathol Biol (Paris). 1993 Jun;41(6):531-6.
The activity of vancomycin (Va) and teicoplanin (Tc) against 114 coagulase-negative staphylococci (CNS) strains was evaluated by disk-diffusion and agar dilution minimal inhibitory concentration (MIC) determination. Results were analysed by species and methicillin-resistance (MR) status. MICs for Va were in the susceptible range (< 4 mg/l) for all strains, with inhibition zone diameters of 17 mm or more in every case. MICs for teicoplanin were 8 or 16 mg/l for 19 CNS strains (including 18 with MR) of which 14 yielded an inhibition zone diameter of 17 mm or more (false susceptibility). Parameters which should lead to MIC determination for Tc regardless of disk diffusion findings include the species (S. haemolyticus), methicillin resistance, Tc zone diameter, and an at least 3 mm difference between the Va and Tc zone diameters.
通过纸片扩散法和琼脂稀释法测定最低抑菌浓度（MIC），评估了万古霉素（Va）和替考拉宁（Tc）对114株凝固酶阴性葡萄球菌（CNS）的活性。结果按菌种和耐甲氧西林（MR）状态进行分析。所有菌株的Va MIC均在敏感范围内（<4mg/l），每种情况下抑菌圈直径均为17mm或更大。19株CNS菌株（包括18株MR菌株）的替考拉宁MIC为8或16mg/l，其中14株抑菌圈直径为17mm或更大（假敏感）。无论纸片扩散结果如何，应进行替考拉宁MIC测定的参数包括菌种（溶血葡萄球菌）、耐甲氧西林、替考拉宁抑菌圈直径以及万古霉素和替考拉宁抑菌圈直径至少相差3mm。
