四氧嘧啶诱导糖尿病中的脑D1多巴胺受体

Brain D1 dopamine receptor in alloxan-induced diabetes.

作者信息

Salković M, Lacković Z

机构信息

Department of Pharmacology, Medical School, University of Zagreb, Republic of Croatia.

出版信息

Diabetes. 1992 Sep;41(9):1119-21. doi: 10.2337/diab.41.9.1119.

DOI:10.2337/diab.41.9.1119

PMID:1386820

Abstract

Specific binding of [3H]SCH 23390 to dopamine D1 receptors in the striatum and olfactory tubercle in 14-day alloxan-induced diabetic rats was investigated. The Scatchard analysis revealed decreased D1 receptor density in the striatum (Bmax values were 548 +/- 23 fmol/mg protein for the control and 466 +/- 33 fmol/mg for the diabetic rats). No change was observed in the olfactory tubercle (Bmax; 299 +/- 27 fmol/mg for the control and 317 +/- 32 fmol/mg for the diabetic rats). Thus, specific binding of [3H]SCH 23390 to striatal and olfactory tubercle membranes showed region-specific changes of brain dopamine D1 receptors in alloxan diabetic rats.

摘要

研究了[3H]SCH 23390与14天四氧嘧啶诱导的糖尿病大鼠纹状体和嗅结节中多巴胺D1受体的特异性结合。Scatchard分析显示，纹状体中D1受体密度降低（对照组的Bmax值为548±23 fmol/mg蛋白质，糖尿病大鼠为466±33 fmol/mg）。嗅结节中未观察到变化（Bmax；对照组为299±27 fmol/mg，糖尿病大鼠为317±32 fmol/mg）。因此，[3H]SCH 23390与纹状体和嗅结节膜的特异性结合显示了四氧嘧啶糖尿病大鼠脑多巴胺D1受体的区域特异性变化。