克拉霉素-环丙沙星-阿米卡星用于治疗艾滋病患者的鸟分枝杆菌-胞内分枝杆菌菌血症。
Clarithromycin-ciprofloxacin-amikacin for therapy of Mycobacterium avium-Mycobacterium intracellulare bacteremia in patients with AIDS.
作者信息
de Lalla F, Maserati R, Scarpellini P, Marone P, Nicolin R, Caccamo F, Rigoli R
机构信息
Department of Infectious Diseases, S. Bortolo Hospital, Vicenza, Italy.
出版信息
Antimicrob Agents Chemother. 1992 Jul;36(7):1567-9. doi: 10.1128/AAC.36.7.1567.
Abstract
A combination of clarithromycin, ciprofloxacin, and amikacin for the treatment of Mycobacterium avium-Mycobacterium intracellulare bacteremia was evaluated in 12 AIDS patients. Mycobacteremia cleared in all patients by 2 to 8 weeks of treatment, and symptoms resolved. Four patients died; all had negative blood cultures until death, and disseminated M. avium-M. intracellulare complex infection was not considered the primary cause of death.
摘要
对12例艾滋病患者评估了克拉霉素、环丙沙星和阿米卡星联合治疗鸟分枝杆菌-胞内分枝杆菌菌血症的疗效。所有患者在治疗2至8周时菌血症均清除，症状缓解。4例患者死亡；所有患者直至死亡时血培养均为阴性，播散性鸟分枝杆菌-胞内分枝杆菌复合感染不被认为是主要死因。
相似文献
1
Clarithromycin-ciprofloxacin-amikacin for therapy of Mycobacterium avium-Mycobacterium intracellulare bacteremia in patients with AIDS.克拉霉素-环丙沙星-阿米卡星用于治疗艾滋病患者的鸟分枝杆菌-胞内分枝杆菌菌血症。
Antimicrob Agents Chemother. 1992 Jul;36(7):1567-9. doi: 10.1128/AAC.36.7.1567.
2
Treatment of Mycobacterium avium complex bacteremia in AIDS with a four-drug oral regimen. Rifampin, ethambutol, clofazimine, and ciprofloxacin. The California Collaborative Treatment Group.采用含四种药物的口服方案治疗艾滋病患者的鸟分枝杆菌复合群菌血症。利福平、乙胺丁醇、氯法齐明和环丙沙星。加利福尼亚协作治疗组。
Ann Intern Med. 1992 Mar 15;116(6):466-72. doi: 10.7326/0003-4819-116-6-466.
3
Treatment of disseminated Mycobacterium avium complex infection in AIDS with amikacin, ethambutol, rifampin, and ciprofloxacin. California Collaborative Treatment Group.使用阿米卡星、乙胺丁醇、利福平及环丙沙星治疗艾滋病患者的播散性鸟分枝杆菌复合群感染。加利福尼亚协作治疗组。
Ann Intern Med. 1990 Sep 1;113(5):358-61. doi: 10.7326/0003-4819-113-5-358.
4
A comparison of two regimens for the treatment of Mycobacterium avium complex bacteremia in AIDS: rifabutin, ethambutol, and clarithromycin versus rifampin, ethambutol, clofazimine, and ciprofloxacin. Canadian HIV Trials Network Protocol 010 Study Group.两种治疗艾滋病患者鸟分枝杆菌复合群菌血症方案的比较：利福布汀、乙胺丁醇和克拉霉素与利福平、乙胺丁醇、氯法齐明和环丙沙星。加拿大HIV试验网络方案010研究组。
N Engl J Med. 1996 Aug 8;335(6):377-83. doi: 10.1056/NEJM199608083350602.
5
Azithromycin for treatment of Mycobacterium avium-intracellulare complex infection in patients with AIDS.阿奇霉素用于治疗艾滋病患者的鸟分枝杆菌复合群感染。
Lancet. 1991 Nov 2;338(8775):1107-9. doi: 10.1016/0140-6736(91)91965-w.
6
A phase II/III trial of antimicrobial therapy with or without amikacin in the treatment of disseminated Mycobacterium avium infection in HIV-infected individuals. AIDS Clinical Trials Group Protocol 135 Study Team.一项关于在感染人类免疫缺陷病毒（HIV）的个体中使用或不使用阿米卡星进行抗微生物治疗播散性鸟分枝杆菌感染的II/III期试验。艾滋病临床试验组方案135研究团队。
AIDS. 1998 Dec 24;12(18):2439-46. doi: 10.1097/00002030-199818000-00013.
7
Activity of clarithromycin against Mycobacterium avium infection in patients with the acquired immune deficiency syndrome. A controlled clinical trial.克拉霉素对获得性免疫缺陷综合征患者鸟分枝杆菌感染的活性。一项对照临床试验。
Am Rev Respir Dis. 1991 Sep;144(3 Pt 1):564-9. doi: 10.1164/ajrccm/144.3_Pt_1.564.
8
Successful short-term suppression of clarithromycin-resistant Mycobacterium avium complex bacteremia in AIDS. California Collaborative Treatment Group.艾滋病患者中克拉霉素耐药鸟分枝杆菌复合菌血症的成功短期抑制。加利福尼亚协作治疗组。
Clin Infect Dis. 1999 Jan;28(1):136-8. doi: 10.1086/515078.
9
Clarithromycin monotherapy of MAC-mycobacteriosis in AIDS patients.艾滋病患者鸟分枝杆菌复合群（MAC）感染的克拉霉素单药治疗
Neth J Med. 1991 Aug;39(1-2):126-7.
10
New antibiotics look good against M. avium.新型抗生素对鸟分枝杆菌显示出良好疗效。
Am J Nurs. 1992 Jan;92(1):12.
引用本文的文献
1
Antimycobacterial agents differ with respect to their bacteriostatic versus bactericidal activities in relation to time of exposure, mycobacterial growth phase, and their use in combination.抗分枝杆菌药物在抑菌与杀菌活性方面存在差异，这与暴露时间、分枝杆菌生长阶段以及联合使用情况有关。
Antimicrob Agents Chemother. 2005 Jun;49(6):2387-98. doi: 10.1128/AAC.49.6.2387-2398.2005.
2
Drug treatment of HIV-related opportunistic infections.艾滋病相关机会性感染的药物治疗。
Drugs. 1997 Jan;53(1):40-73. doi: 10.2165/00003495-199753010-00004.
3
In vitro activities of rifabutin, azithromycin, ciprofloxacin, clarithromycin, clofazimine, ethambutol, and amikacin in combinations of two, three, and four drugs against Mycobacterium avium.利福布汀、阿奇霉素、环丙沙星、克拉霉素、氯法齐明、乙胺丁醇和阿米卡星两两、三三及四四联合用药对鸟分枝杆菌的体外活性。
Antimicrob Agents Chemother. 1996 Mar;40(3):743-9. doi: 10.1128/AAC.40.3.743.
4
Susceptibility testing of Mycobacterium avium complex isolates.鸟分枝杆菌复合体分离株的药敏试验
Antimicrob Agents Chemother. 1996 Aug;40(8):1759-67. doi: 10.1128/AAC.40.8.1759.
5
Clarithromycin prophylaxis against Cryptosporidium enteritis in patients with AIDS.克拉霉素预防艾滋病患者隐孢子虫肠炎。
J Natl Med Assoc. 1996 Jul;88(7):425-7.
6
Evaluation of the anti-rickettsial activity of fluoroquinolones.氟喹诺酮类药物抗立克次氏体活性的评估。
Drugs. 1995;49 Suppl 2:208-10. doi: 10.2165/00003495-199500492-00044.
7
The Mycobacterium avium complex.鸟分枝杆菌复合体
Clin Microbiol Rev. 1993 Jul;6(3):266-310. doi: 10.1128/CMR.6.3.266.
8
Clarithromycin, minocycline, and rifabutin treatments before and after infection of C57BL/6 mice with Mycobacterium avium.用鸟分枝杆菌感染C57BL/6小鼠前后给予克拉霉素、米诺环素和利福布汀治疗。
Antimicrob Agents Chemother. 1993 Aug;37(8):1690-2. doi: 10.1128/AAC.37.8.1690.
9
Effectiveness of various antimicrobial agents against Mycobacterium avium complex in the beige mouse model.在米色小鼠模型中各种抗菌剂对鸟分枝杆菌复合群的有效性。
Antimicrob Agents Chemother. 1994 Nov;38(11):2521-9. doi: 10.1128/AAC.38.11.2521.
10
Selection of clarithromycin-resistant Mycobacterium avium complex during combined therapy using the beige mouse model.使用米色小鼠模型在联合治疗期间对克拉霉素耐药鸟分枝杆菌复合群的选择。
Antimicrob Agents Chemother. 1995 Mar;39(3):608-12. doi: 10.1128/AAC.39.3.608.
本文引用的文献
1
Infections caused by Mycobacterium avium complex in immunocompromised patients: diagnosis by blood culture and fecal examination, antimicrobial susceptibility tests, and morphological and seroagglutination characteristics.免疫功能低下患者鸟分枝杆菌复合群感染：通过血培养和粪便检查进行诊断、抗菌药敏试验以及形态学和血清凝集特征
J Clin Microbiol. 1985 Feb;21(2):168-73. doi: 10.1128/jcm.21.2.168-173.1985.
2
Effect of combined clofazimine and ansamycin therapy on Mycobacterium avium-Mycobacterium intracellulare bacteremia in patients with AIDS.氯法齐明与安莎霉素联合治疗对艾滋病患者鸟分枝杆菌-胞内分枝杆菌菌血症的影响。
J Infect Dis. 1987 Jan;155(1):127-9. doi: 10.1093/infdis/155.1.127.
3
Determination of in vitro susceptibility of Mycobacterium avium complex isolates to antimycobacterial agents by various methods.通过多种方法测定鸟分枝杆菌复合群分离株对抗分枝杆菌药物的体外敏感性。
Antimicrob Agents Chemother. 1987 Nov;31(11):1697-702. doi: 10.1128/AAC.31.11.1697.
4
Comparative in vitro activity of the new macrolide A-56268 against mycobacteria.新型大环内酯类药物A-56268对分枝杆菌的体外活性比较
Eur J Clin Microbiol. 1987 Aug;6(4):486-7. doi: 10.1007/BF02013117.
5
In vitro and in vivo evaluation of A-56268 (TE-031), a new macrolide.新型大环内酯类药物A-56268（TE-031）的体外和体内评估
Antimicrob Agents Chemother. 1986 Dec;30(6):865-73. doi: 10.1128/AAC.30.6.865.
6
Amikacin, ciprofloxacin, and imipenem treatment for disseminated Mycobacterium avium complex infection of beige mice.阿米卡星、环丙沙星和亚胺培南治疗米色小鼠播散性鸟分枝杆菌复合群感染
Antimicrob Agents Chemother. 1989 Feb;33(2):176-80. doi: 10.1128/AAC.33.2.176.
7
Comparative in-vitro activity of twenty antimicrobial agents against clinical isolates of Mycobacterium avium complex.二十种抗菌剂对鸟分枝杆菌复合群临床分离株的体外活性比较
J Antimicrob Chemother. 1989 Nov;24(5):667-73. doi: 10.1093/jac/24.5.667.
8
Mycobacterium avium and Mycobacterium intracellulare infections in patients with and without AIDS.艾滋病患者与非艾滋病患者的鸟分枝杆菌和胞内分枝杆菌感染。
J Infect Dis. 1989 Dec;160(6):1037-41. doi: 10.1093/infdis/160.6.1037.
9
In vitro and in vivo activities of clarithromycin against Mycobacterium avium.克拉霉素对鸟分枝杆菌的体外及体内活性
Antimicrob Agents Chemother. 1989 Sep;33(9):1531-4. doi: 10.1128/AAC.33.9.1531.
10
Comparison of bactericidal activities of streptomycin, amikacin, kanamycin, and capreomycin against Mycobacterium avium and M. tuberculosis.链霉素、阿米卡星、卡那霉素和卷曲霉素对鸟分枝杆菌和结核分枝杆菌杀菌活性的比较。
Antimicrob Agents Chemother. 1989 Aug;33(8):1298-301. doi: 10.1128/AAC.33.8.1298.
Zotero 插件