在米色小鼠模型中各种抗菌剂对鸟分枝杆菌复合群的有效性。
Effectiveness of various antimicrobial agents against Mycobacterium avium complex in the beige mouse model.
作者信息
Ji B, Lounis N, Truffot-Pernot C, Grosset J
机构信息
Bactériologie et Virologie, Faculté de Médecine Pitié-Salpêtrière, Paris, France.
出版信息
Antimicrob Agents Chemother. 1994 Nov;38(11):2521-9. doi: 10.1128/AAC.38.11.2521.
Abstract
The results of five chemotherapeutic experiments in beige mice infected with organisms of the Mycobacterium avium complex are presented. After monotherapy with various antimicrobial agents for 4 weeks, only clarithromycin, amikacin, and ethambutol displayed definite bactericidal effects; sparfloxacin and clofazimine showed modest bacteriostatic effects; and rifampin and rifabutin were totally inactive against the isolate tested. After treatment for 4 weeks, the large quantities of clofazimine that had accumulated in the organs of mice seriously interfered with the enumeration of the CFU and assessment of the efficacy of the treatment. The in vitro synergistic effects of drug combinations against M. avium complex were not confirmed in beige mice. In combination with clarithromycin, amikacin could prevent the selection of clarithromycin-resistant mutants, whereas minocycline could not.
摘要
本文展示了五项针对感染鸟分枝杆菌复合群微生物的米色小鼠的化疗实验结果。用各种抗菌药物进行单药治疗4周后，只有克拉霉素、阿米卡星和乙胺丁醇显示出明确的杀菌作用；司帕沙星和氯法齐明表现出适度的抑菌作用；利福平和利福布汀对测试分离株完全无活性。治疗4周后，小鼠器官中积累的大量氯法齐明严重干扰了菌落形成单位（CFU）的计数和治疗效果评估。药物组合对鸟分枝杆菌复合群的体外协同作用在米色小鼠中未得到证实。与克拉霉素联合使用时，阿米卡星可防止克拉霉素耐药突变体的产生，而米诺环素则不能。
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本文引用的文献
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Powerful bactericidal activity of sparfloxacin (AT-4140) against Mycobacterium tuberculosis in mice.司帕沙星（AT-4140）对小鼠体内结核分枝杆菌具有强大的杀菌活性。
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In-vitro antimycobacterial activity of minocycline.米诺环素的体外抗分枝杆菌活性。
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Confirmation of the beige mouse model for study of disseminated infection with Mycobacterium avium complex.用于研究鸟分枝杆菌复合群播散性感染的米色小鼠模型的确认。
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