用鸟分枝杆菌感染C57BL/6小鼠前后给予克拉霉素、米诺环素和利福布汀治疗。
Clarithromycin, minocycline, and rifabutin treatments before and after infection of C57BL/6 mice with Mycobacterium avium.
作者信息
Lazard T, Perronne C, Grosset J, Vilde J L, Pocidalo J J
机构信息
Institut National de la Santé et de la Recherche Médicale, Unité 13, Hôpital Bichat-Claude Bernard, Paris, France.
出版信息
Antimicrob Agents Chemother. 1993 Aug;37(8):1690-2. doi: 10.1128/AAC.37.8.1690.
Abstract
C57BL/6 mice were pretreated with rifabutin or clarithromycin alone or combined with minocycline 3 days before intravenous challenge (day 0) with Mycobacterium avium. Treatment was continued until sacrifice at days 1, 8, 15, and 21. Rifabutin or clarithromycin decreased the level of infection in both the lungs and the spleen. Rifabutin was as effective as clarithromycin in the lungs but was less [corrected] effective in the spleen. The clarithromycin-minocycline combination was as effective as clarithromycin alone.
摘要
在静脉注射鸟分枝杆菌（第0天）前3天，对C57BL/6小鼠单独用利福布汀或克拉霉素预处理，或与米诺环素联合预处理。治疗持续至第1、8、15和21天处死小鼠。利福布汀或克拉霉素降低了肺和脾中的感染水平。利福布汀在肺中的效果与克拉霉素相当，但在脾中的效果较差[校正后]。克拉霉素-米诺环素联合用药与单独使用克拉霉素效果相当。
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