Dacquet V, Varlet A, Tandogan R N, Tahon M M, Fournier L, Jehl F, Monteil H, Bascoulergue G
Institut Calot, Berck-sur-Mer, France.
Clin Orthop Relat Res. 1992 Sep(282):241-9.
Teicoplanin-impregnated plaster of Paris beads were made and in vitro release properties were studied. Teicoplanin was released in an initial massive dose, with a rapid decline during the first three days, followed by a slowly declining prolonged release up to 30 days. The release tested by diffusion in gelose and high-performance liquid chromatography was found to be 21.4% and 28.2%, respectively, of the amount theoretically present in the beads. Plaster of Paris is a resorbable, nontoxic biomaterial that has already been used to fill dead spaces in bone and deliver antibiotics in the treatment of chronic osteomyelitis. The addition of teicoplanin, a new antistaphylococcal agent with low known bacterial resistance, is a promising alternative. Follow-up tests in vivo, simulating local conditions of the osteomyelitic bone, are necessary to prove efficacy.
制备了含替考拉宁的巴黎石膏珠，并对其体外释放特性进行了研究。替考拉宁以初始大剂量释放，在头三天迅速下降，随后在长达30天的时间里缓慢下降并持续释放。通过在琼脂糖中扩散和高效液相色谱法测试发现，释放量分别为珠子中理论存在量的21.4%和28.2%。巴黎石膏是一种可吸收、无毒的生物材料，已被用于填充骨内死腔并在慢性骨髓炎治疗中递送抗生素。添加替考拉宁，一种已知细菌耐药性低的新型抗葡萄球菌药物，是一种有前景的替代方法。有必要进行模拟骨髓炎骨局部情况的体内随访试验以证明疗效。
