Henrotin Y, Bassleer C, Franchimont P
Laboratory of Radioimmunoassay, University of Liège, C.H.U., Belgium.
Agents Actions. 1992 Jul;36(3-4):317-23.
The effects of two nonsteroidal anti-inflammatory drugs (NSAIDs), Etodolac (ETO) and acetylsalicylic acid (ASA), used at pharmacological concentrations, were tested on several metabolic parameters of human chondrocytes cultivated in three-dimensional culture. The results indicated that proteoglycan synthesis was significantly decreased by ASA treatment, whereas Etodolac did not affect this parameter. Neither ASA nor Etodolac modified type-II collagen production. Both NSAIDs were potent inhibitors of PGE2 production, but Etodolac was more efficient at equimolar concentrations. In contrast, collagenolytic activity was unaffected by Etodolac.
在三维培养体系中培养的人软骨细胞的多个代谢参数上，测试了两种非甾体抗炎药（NSAIDs）依托度酸（ETO）和乙酰水杨酸（ASA）在药理浓度下的作用。结果表明，ASA处理显著降低了蛋白聚糖的合成，而依托度酸不影响该参数。ASA和依托度酸均未改变II型胶原蛋白的产生。两种NSAIDs都是PGE2产生的有效抑制剂，但在等摩尔浓度下，依托度酸更有效。相反，胶原分解活性不受依托度酸影响。
