Walker R I, Shields L J, Fletcher J R
Infect Immun. 1978 Mar;19(3):919-22. doi: 10.1128/iai.19.3.919-922.1978.
Endotoxin may cause abnormal deposition of platelet-endotoxin aggregates, and this event could have damaging effects. We compared the aggregation characteristics of platelets from rabbits made tolerant to the lethal effects of endotoxin with those of platelets from normal rabbits. Platelets from tolerant rabbits aggregated more rapidly (greater than 90 s faster) in the presence of endotoxin than did platelets from nontolerant animals. Furthermore, platelets from tolerant animals aggregated reversibly. These characteristics of platelets from tolerant animals are due to humoral factors in the plasma, because 1:1 dilution of normal platelet-rich plasma with plasma from tolerant rabbits caused the normal platelets to behave like those from tolerant animals. Survival after challenge with lethal quantities of endotoxin was enhanced in tolerant rabbits; this may be due to promotion of more efficient removal of endotoxin-platelet complexes from the blood by the reticuloendothelial system.
内毒素可能导致血小板-内毒素聚集体异常沉积，而这一事件可能会产生破坏性影响。我们比较了对内毒素致死效应产生耐受的兔子的血小板与正常兔子的血小板的聚集特性。在存在内毒素的情况下，耐受兔子的血小板比未耐受动物的血小板聚集得更快（快90秒以上）。此外，耐受动物的血小板聚集是可逆的。耐受动物血小板的这些特性归因于血浆中的体液因子，因为用耐受兔子的血浆对正常富含血小板的血浆进行1:1稀释会使正常血小板的行为与耐受动物的血小板相似。耐受兔子在接受致死量内毒素攻击后的存活率提高；这可能是由于网状内皮系统促进了血液中内毒素-血小板复合物的更有效清除。
