对马德拉斯接种疫苗的成年人群样本血清中天花抗体水平的研究。
Studies of smallpox antibody levels of sera from samples of the vaccinated adult population of Madras.
作者信息
DOWNIE A W, HOBDAY T L, ST VINCENT L, KEMPE C H
出版信息
Bull World Health Organ. 1961;25(1):55-61.
In view of the endemicity of smallpox in Madras and the poor take rate on revaccination with the lymph in current use, it was felt that the immunity of the general adult population might be relatively low. In an attempt to obtain some measure of this, sera were obtained from over 300 adults in Madras for the estimation of serum antibody. The results of neutralization tests against variola virus made on these sera showed that about 10% of those who had good scars from infant vaccination showed little or no antibody. A comparison of the antibody titres of adult sera showing good antibody levels when used undiluted was made with that of sera from smallpox convalescents. The antibody level in the latter sera was 20-100 times that of the sera of adult persons who showed good vaccination scars.
鉴于马德拉斯地区天花的地方性流行情况以及当前使用的痘苗接种后复种的接受率较低，人们认为一般成年人群的免疫力可能相对较低。为了对此进行某种程度的评估，从马德拉斯的300多名成年人中采集了血清以检测血清抗体。对这些血清进行的针对天花病毒的中和试验结果表明，那些婴儿接种后留有良好疤痕的人中，约10%的人几乎没有或没有抗体。将未稀释时显示出良好抗体水平的成年血清的抗体滴度与天花康复者的血清进行了比较。后者血清中的抗体水平是显示有良好接种疤痕的成年人血清抗体水平的20至100倍。
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