Jäättelä M, Wissing D
Department of Tumor Cell Biology, Fibiger Institute, Copenhagen, Denmark.
Ann Med. 1992 Aug;24(4):249-58. doi: 10.3109/07853899209149952.
All cells, procaryotic and eucaryotic, respond to an elevation in temperature by increasing the synthesis of a family of proteins collectively known as heat shock proteins (HSPs). HSPs are among the most highly conserved and abundant proteins in nature. Studies on the regulation of the synthesis of HSPs have for several years shed light on the mechanisms regulating gene expression. The results from recent years, showing that HSPs play crucial roles in a wide variety of normal cellular processes, has made them an object of even broader interest, first to molecular and cellular biologists and later to specialists in various fields of medicine including oncology, immunology, infectious disease, autoimmunity, embryology, neurology and endocrinology. The aim of this review is to briefly summarize our present knowledge of the regulation of the heat shock response and the structure of the relevant gene products, HSPs. Moreover, some of the exciting associations between HSPs and various fields of medicine will be discussed.
所有细胞，包括原核细胞和真核细胞，都会通过增加一类统称为热休克蛋白（HSPs）的蛋白质的合成来响应温度升高。热休克蛋白是自然界中最高度保守且含量丰富的蛋白质之一。多年来，对热休克蛋白合成调控的研究揭示了基因表达调控的机制。近年来的研究结果表明，热休克蛋白在多种正常细胞过程中发挥着关键作用，这使得它们首先成为分子和细胞生物学家，随后成为包括肿瘤学、免疫学、传染病学、自身免疫性疾病、胚胎学、神经学和内分泌学等各个医学领域专家更广泛关注的对象。本综述的目的是简要总结我们目前对热休克反应调控及相关基因产物——热休克蛋白结构的认识。此外，还将讨论热休克蛋白与各个医学领域之间一些令人兴奋的关联。
