Joerring S, Jensen L T, Andersen G R, Johansen J S
Department of Orthopedics A, Frederiksberg Hospital, Denmark.
Arch Orthop Trauma Surg. 1992;111(5):265-7. doi: 10.1007/BF00571521.
Markers of types I and III collagen turnover were measured in serial blood samples in 16 patients with a Colles' fracture. The collagen markers were the carboxy-terminal extension peptide of type I procollagen (PICP) and the amino-terminal extension peptide of type III procollagen (PIIINP). Significant increases were found of PIIINP within 1 week and of PICP within 2 weeks. This sequential appearance of PIIINP and PICP was found to be in agreement with the appearance of types III and I collagen during early fracture healing as demonstrated in previous animal experimental studies. PICP had levelled off after 9 months, whereas PIIINP remained elevated. Osteocalcin, a serum marker of osteoblast activity, increased within 1 week and levelled off after 9 months. Correlations between the change in osteocalcin and those in PICP and PIIINP, respectively, were weak. These new biochemical markers may prove relevant as non-invasive markers of normal and pathological fracture healing in humans.
对16例Colles骨折患者的系列血样进行了I型和III型胶原转换标志物的检测。胶原标志物为I型前胶原羧基末端延长肽（PICP）和III型前胶原氨基末端延长肽（PIIINP）。发现PIIINP在1周内显著升高，PICP在2周内显著升高。如先前动物实验研究所示，PIIINP和PICP的这种相继出现与骨折早期愈合过程中III型和I型胶原的出现一致。9个月后PICP趋于平稳，而PIIINP仍处于升高状态。骨钙素是成骨细胞活性的血清标志物，在1周内升高，9个月后趋于平稳。骨钙素变化与PICP和PIIINP变化之间的相关性较弱。这些新的生化标志物可能被证明是人类正常和病理性骨折愈合的非侵入性标志物。
