Obrant K J, Merle B, Bejui J, Delmas P D
INSERM Unit 234, Hôpital Edouard Herriot, Lyon, France.
Clin Orthop Relat Res. 1990 Sep(258):300-3.
Serum bone Gamma-carboxyglutamic acid (bone-gla) protein (BGP), a marker of bone formation, was measured in serial blood samples drawn from 14 patients who had fractured at least one of their tibial or femoral diaphyses and from two other patients who had sustained major trauma without fracture but who had been immobilized. A total of 85 samples were taken and analyzed during the first three months after the fractures occurred. Serum BGP significantly increased and positively correlated with the time that had elapsed after the fracture, with an average twofold increase after two months. The fracture site and the duration of immobilization had no influence on the serum BGP levels. Serum BGP levels from the two non-fractured cases increased in the first two weeks with no subsequent consistent trend. These data suggest that serum BGP increases one to two months after a major fracture, possibly as a manifestation of bone repair. Further studies are required to determine the potential clinical value of serum BGP in the management of such patients.
血清骨γ-羧基谷氨酸蛋白（骨钙素，BGP）是一种骨形成标志物，在取自14例胫骨干或股骨干至少发生一处骨折患者以及另外2例遭受严重创伤但未骨折但已制动的患者的系列血样中进行了检测。在骨折发生后的头三个月内共采集并分析了85份样本。血清BGP显著升高，且与骨折后经过的时间呈正相关，两个月后平均升高两倍。骨折部位和制动时间对血清BGP水平无影响。2例未骨折病例的血清BGP水平在前两周升高，随后无一致趋势。这些数据表明，严重骨折后1至2个月血清BGP升高，可能是骨修复的一种表现。需要进一步研究以确定血清BGP在这类患者管理中的潜在临床价值。
