锥形活检：宫颈管取样有作用吗？
Cone biopsy: has endocervical sampling a role?
作者信息
Anderson D J, Strachan F, Parkin D E
机构信息
Harris Birthright Centre for the Prevention of Cervical Cancer, Aberdeen Royal Infirmary.
出版信息
Br J Obstet Gynaecol. 1992 Aug;99(8):668-70. doi: 10.1111/j.1471-0528.1992.tb13852.x.
OBJECTIVE
To investigate the sensitivity, specificity and predictive value of endocervical sampling in women with abnormal cervical smears.
DESIGN
A randomized study of two methods of endocervical sampling.
SETTING
Colposcopy clinic at Aberdeen Royal Infirmary.
SUBJECTS
100 women with abnormal cervical smears selected for cone biopsy according to current colposcopy criteria.
INTERVENTIONS
53 women were randomized to have endocervical sampling with the Kevorkian curette and 47 to have sampling with the Medscand endocervical brush.
MAIN OUTCOME MEASURES
Cytology and histology results from endocervical sampling compared with cone biopsy histology.
RESULTS
The overall sensitivity of endocervical sampling was 56%, with a false negative rate of 44% and a negative predictive value of 26%.
CONCLUSIONS
Endocervical sampling should not influence management when colposcopy is unsatisfactory.
目的
探讨宫颈涂片异常女性宫颈管取样的敏感性、特异性及预测价值。
设计
两种宫颈管取样方法的随机研究。
地点
阿伯丁皇家医院阴道镜诊所。
研究对象
根据当前阴道镜标准选择100例宫颈涂片异常且需行锥形活检的女性。
干预措施
53例女性随机采用凯沃尔基安刮匙进行宫颈管取样，47例采用美迪声宫颈刷取样。
主要观察指标
宫颈管取样的细胞学和组织学结果与锥形活检组织学结果进行比较。
结果
宫颈管取样的总体敏感性为56%，假阴性率为44%，阴性预测值为26%。
结论
当阴道镜检查不满意时，宫颈管取样不应影响治疗决策。
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