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视神经乳头杯盘比的双生子研究。

Twin study on cup/disc ratio of the optic nerve head.

作者信息

Teikari J M, Airaksinen J P

机构信息

University of Helsinki, Department of Ophthalmology, Finland.

出版信息

Br J Ophthalmol. 1992 Apr;76(4):218-20. doi: 10.1136/bjo.76.4.218.

Abstract

Seventeen healthy twin pairs (10 monozygotic and seven dizygotic) from the Finnish Twin Cohort Study were examined to study the impact of heredity v environment in the determination of cup-to-disc area ratio. These twins were free from any known eye disease. The cup/disc ratio was determined using stereo photography and a computer assisted analysis technique. The zygosity of all twin pairs was confirmed with the DNA 'fingerprint' technique. The intrapair correlations were high among monozygotic pairs compared with those among dizygotic twin pairs. The difference of cup/disc area ratios between the right eyes of members of monozygotic twin pairs was statistically significantly smaller than that of dizygotic twin pairs (p < 0.001). The same was true for left eyes (p < 0.01). This result confirms a genetic determination in cup/disc area ratio in normal eyes.

摘要

对来自芬兰双胞胎队列研究的17对健康双胞胎(10对同卵双胞胎和7对异卵双胞胎)进行了检查,以研究遗传因素和环境因素对杯盘面积比测定的影响。这些双胞胎没有任何已知的眼部疾病。杯盘比通过立体摄影和计算机辅助分析技术来测定。所有双胞胎对的合子性通过DNA“指纹”技术得以确认。与异卵双胞胎对相比,同卵双胞胎对之间的组内相关性更高。同卵双胞胎对成员右眼杯盘面积比的差异在统计学上显著小于异卵双胞胎对(p < 0.001)。左眼情况同样如此(p < 0.01)。这一结果证实了正常眼睛杯盘面积比受遗传因素的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b162/504231/dd9381439ede/brjopthal00052-0026-a.jpg

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