水貂实验性高丙种球蛋白血症
Experimental hypergammaglobulinemia in mink.
作者信息
HENSON J B, GORHAM J R, LEADER R W, WAGNER B M
出版信息
J Exp Med. 1962 Sep 1;116(3):357-64. doi: 10.1084/jem.116.3.357.
Hypergammaglobulinemia in mink was produced by the injection of crude tissue suspensions from mink with spontaneous Aleutian disease. The initiating factor was found to be resistant to 0.3 per cent formalin for 2 weeks but not 40 weeks at 5 degrees C. Foreign antigens as well as formalinized normal mink tissue from homologous and heterologous genotypes did not cause a detectable change in the serum protein values. Mink homozygous recessive for the Aleutian gene were found to be significantly more susceptible to the experimental disease. Possible pathogenetic mechanisms as well as similarities between the mink disease and certain immunologic and connective tissue diseases of man are discussed.
通过注射患有自发性阿留申病的水貂的粗组织悬液，在水貂中诱发了高丙种球蛋白血症。发现起始因子在5摄氏度下对0.3%福尔马林耐受2周，但不耐受40周。来自同源和异源基因型的外来抗原以及经福尔马林处理的正常水貂组织并未导致血清蛋白值出现可检测到的变化。发现阿留申基因纯合隐性的水貂对实验性疾病的易感性明显更高。讨论了可能的发病机制以及水貂疾病与人类某些免疫和结缔组织疾病之间的相似性。
Zotero 插件