Ciais G, Namer M, Schneider M, Demard F, Pourreau-Schneider N, Martin P M, Soudry M, Franquin J C, Zattara H
Centre de lutte contre le cancer Antoine-Lacassagne, Nice, France.
Bull Cancer. 1992;79(2):183-91.
The appearance of mucositis is a frequent and painful secondary effect of anticancer chemotherapy. Patients who develop oral toxicity during the first course of treatment will almost assuredly show identical side effects during each subsequent course unless the drugs are changed or the doses are lowered. In the absence of an efficacious antidote or preventive prophylaxis for such lesions to date, this report presents the results of a preliminary retrospective non-randomized study of the effect of soft-laser treatments on mucositis in cancer patients receiving combination chemotherapy, including 5-fluorouracil. Iatrogenic mucositis was observed during 43% of 53 chemotherapy cycles in the case control population. Curative laser therapy reduced the time to repair lesions and the rate of therapeutic modifications. For patients who received soft-laser therapy as a preventive measure, the incidence of oral complications was reduced to 6% during 101 cycles of chemotherapy. All of these patients, even those who have encountered mucositis before receiving preventive laser therapy, terminated their cancer therapy as originally scheduled. Well designed and carefully controlled trials will be necessary to define the place of helium-neon laser therapy in the repair and prevention of oral complications due to cancer chemotherapy.
黏膜炎的出现是抗癌化疗常见且痛苦的副作用。在首个疗程中出现口腔毒性的患者，除非更换药物或降低剂量，否则在随后的每个疗程中几乎肯定会出现相同的副作用。由于迄今为止尚无针对此类病变的有效解毒剂或预防性预防措施，本报告展示了一项初步回顾性非随机研究的结果，该研究探讨了软激光治疗对接受包括5-氟尿嘧啶在内的联合化疗的癌症患者黏膜炎的影响。在病例对照人群的53个化疗周期中，有43%观察到医源性黏膜炎。治愈性激光治疗缩短了病变修复时间并降低了治疗调整率。对于接受软激光治疗作为预防措施的患者，在101个化疗周期中，口腔并发症的发生率降至6%。所有这些患者，即使是那些在接受预防性激光治疗前曾出现黏膜炎的患者，也都按原计划完成了癌症治疗。要确定氦氖激光治疗在修复和预防癌症化疗引起的口腔并发症中的地位，还需要精心设计和严格控制的试验。
