Konishi Y, Denda A, Takahashi S, Sunagawa M, Kondo H
Gan. 1976 Dec;67(6):781-6.
The effect of dimethylnitrosamine (DMN), ethionine, streptozotocin, N-methyl-N-nitrosourethan (MNUT), N-bis(2-hydroxypropyl)nitrosamine (DHPN), azaserine, and 4-hydorxyaminoquinoline 1-oxide (4-HAQO) on DNA synthesis after partial pancreatectomy was studied. Its results indicates that DNA synthesis of the residual pancreas occurred and reached the maximum value at 3 days and returned to the control value 12 days after the operation. DNA synthesis, which was inhibited 96.7% by hydroxyurea 3 days after the operation, indicated that semi-conservative DNA synthesis had occurred in the residual pancreas. DMN and ethionine, non-pancreatic carcinogens, did not inhibit while DHPN, MNUT, azaserine, and 4-HAQO, pancreatic non-endocrine carcinogens, inhibited DNA synthesis in the rat pancreas by 57.9, 76.4, 71.7, and 82.1%, respectively. The effect of streptozotocin, pancreatic endocrine carcinogen, on DNA synthesis was not clear from the present experiment. Further effect on the inhibition of DNA synthesis by these carcinogens was obtained by dose-response studies and its results indicated that there was a correlation between pancreatic carcinogens and the inhibition of DNA synthesis after partial pancreatectomy in rats.
研究了二甲基亚硝胺（DMN）、乙硫氨酸、链脲佐菌素、N-甲基-N-亚硝基脲烷（MNUT）、N-双（2-羟丙基）亚硝胺（DHPN）、重氮丝氨酸和4-羟基氨基喹啉1-氧化物（4-HAQO）对部分胰腺切除术后DNA合成的影响。结果表明，残余胰腺的DNA合成在术后3天出现并达到最大值，术后12天恢复到对照值。术后3天羟基脲抑制DNA合成96.7%，这表明残余胰腺发生了半保留DNA合成。非胰腺致癌物DMN和乙硫氨酸没有抑制作用，而胰腺非内分泌致癌物DHPN、MNUT、重氮丝氨酸和4-HAQO分别抑制大鼠胰腺DNA合成57.9%、76.4%、71.7%和82.1%。胰腺内分泌致癌物链脲佐菌素对DNA合成的影响在本实验中尚不清楚。通过剂量反应研究获得了这些致癌物对DNA合成抑制的进一步影响，其结果表明，胰腺致癌物与大鼠部分胰腺切除术后DNA合成的抑制之间存在相关性。
