Leung S F, Kreel L, Tsao S Y
Department of Clinical Oncology, Chinese University of Hong Kong.
Br J Radiol. 1992 Aug;65(776):710-4. doi: 10.1259/0007-1285-65-776-710.
Computed tomography (CT) scans were performed on a cohort of 60 patients for detection of temporal lobe injury (TLI) at 1-3.5 years after radiation therapy for nasopharyngeal carcinoma. Nine cases of TLI were identified, five of which were asymptomatic. The earliest case of asymptomatic TLI was found at 2.2 years after radiation therapy and the earliest symptomatic case at 2.3 years. A significantly higher incidence of TLI was found in patients with decreased temporal lobe shielding consequent to omitted eyeshield to the anterior photon beam and in patients treated with a hyperfractionation schedule giving 67.2 Gy in 42 fractions in 6 weeks. The incidence in these subgroups at 2-3.5 years after radiation therapy was 56% (5/9 patients) and 35% (8/23 patients), respectively. No patient in this study had TLI in the absence of these two factors. The implications of the results are discussed.
对一组60例鼻咽癌放疗后1至3.5年的患者进行了计算机断层扫描（CT），以检测颞叶损伤（TLI）。共发现9例TLI，其中5例无症状。无症状TLI最早出现在放疗后2.2年，有症状的最早出现在2.3年。由于对前部光子束未使用眼罩导致颞叶屏蔽减少的患者，以及采用超分割方案在6周内分42次给予67.2 Gy的患者，TLI发生率显著更高。放疗后2至3.5年，这些亚组中的发生率分别为56%（5/9例患者）和35%（8/23例患者）。本研究中没有患者在不存在这两个因素的情况下发生TLI。讨论了结果的意义。
